Polycystic Ovary Syndrome Clinical Trial
Official title:
Evaluation Of Lipid Peroxidation, Oxidative DNA Damage And Total Antioxidant Status In Patients With Periodontitis And Polycystic Ovary Syndrome: A Cross Sectional Study
Background: The aim of this study was to investigate the levels of malondialdehyde (MDA),
total antioxidant status (TAS), 8-hydroxy-2´- deoxyguanosine (8-OHdG) in blood serum and
saliva samples in female patients with chronic periodontitis (CP) and to compared healthy
individuals.
Materials and Methods: A total of 88 women were into four groups each which were consisted of
twenty-two subjects. Groups were designed as periodontally and systemically healthy women
(PCOS-CP-); periodontally healthy women with polycystic ovary syndrome (PCOS) (PCOS+CP-),
systemically healthy women with CP (PCOS-,CP+) and women with PCOS and CP (PCOS+CP+). Serum
and salivary samples were obtained, clinical periodontal parameters were recorded. MDA, TAS,
8-OHdG levels were measured as biochemically.
RESULTS:
Salivary 8-OHdG levels in the PCOSCP and CP groups were statistically higher than those in
both the PCOSPH and the PH groups (P < 0.05). There was no statistical difference between the
PCOSCP, CP, and PCOSPH groups with regard to salivary MDA and TAS levels (P > 0.05). Highest
serum 8-OHdG and MDA levels and lowest serum TAS levels were seen in the PCOSCP group (P <
0.05). Serum 8-OHdG and MDA levels in the PCOSPH group were higher than those in both
systemically healthy groups (PH and CP) (P < 0.05). Salivary TAS levels were highest (P <
0.05) in the PH group. There was no statistical difference between the CP and PCOSPH groups,
but serum TAS levels were lower than those in the PH group (P < 0.05).
CONCLUSIONS:
CP, which led to an increase in serum and salivary 8-OHdG and MDA levels and a decrease in
serum TAS levels in patients with PCOS, contributed to increased OS. This effect was more
prominent in serum levels than in salivary levels.
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