Polycystic Ovary Syndrome Clinical Trial
Official title:
Obesity, Insulin Resistance, and Bone Metabolism in Adolescents With PCOS: Effects of Insulin Sensitizers Versus Oral Contraceptives
The purpose is to investigate the effects of 2 different treatments (drospirenone/ethinyl estradiol versus rosiglitazone) on insulin sensitivity and androgen levels, inflammatory markers, vascular markers and bone development in overweight adolescent females with polycystic ovary syndrome (PCOS).
The purpose of this study is to:
1) to compare effects of treatment with drospirenone/ethinyl estradiol (Yasmin)versus
rosiglitazone (Avandia) on hyperandrogenism, insulin resistance/hyperinsulinemia, adrenal
hyperresponsiveness, body composition, chronic inflammation, bone mass and turnover.
OCPs are the first-line therapy for PCOS, however, they do not address the insulin resistance
or the inflammation. Insulin sensitizers have been used successfully to treat PCOS but
thiazolidinediones such as rosiglitazone have not been used in adolescents. Therefore we will
investigate the effects of treatment with drospirenone/ethinyl estradiol versus rosiglitazone
in overweight adolescents with PCOS. We will obtain comprehensive evaluations before and 6
months after randomization, to the respective treatment arms to determine the differences
between the 2 treatment modalities.
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