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NCT06103981 Clinical Trial

Acute Liver Injury in Patients With Pneumonia

Pneumonia Clinical Trial

Official title:
Acute Liver Injury in Patients With Pneumonia and Its Impact on Hospital Stay and Outcome

Clinical Trial Details — Status: Not yet recruiting

Administrative data
NCT number NCT06103981
Other study ID # Acute Liver Injury
Secondary ID
Status Not yet recruiting
Phase
First received
Last updated
Start date December 1, 2023
Est. completion date March 10, 2025

Study information
Verified date October 2023
Source Assiut University
Contact Beshoy Yousef, MSc
Phone 01114761284
Email Beshoyyoussef18@gmail.com
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

Acute liver injury (ALI) is defined as an acute derangement in liver function tests associated with liver-related coagulopathy, in the absence of underlying chronic liver disease. A subset progress to acute liver failure ,Acute liver failure represent a more severe liver injury results in hepatic encephalopathy

Description:

Acute liver injury is associated with a spectrum of haemostatic changes, including thrombocytopenia and reduced platelet function, reduced plasma levels of many coagulation factors such as factor (F)VII and increased levels of FVIII . Pneumonia is an acute inflammation of the lower respiratory tract. Lower respiratory tract infection is a major cause of mortality worldwide .Pneumonia is most common at the extremes of life. In adults, pneumonia can be broadly classified, on the basis of chest radiographic appearance, into lobar pneumonia, bronchopneumonia and pneumonia producing an interstitial pattern. There is lack of data regarding outcome and hospital stay in patients with pneumonia who develop acute liver injury.

Recruitment information / eligibility
Status Not yet recruiting
Enrollment 176
Est. completion date March 10, 2025
Est. primary completion date January 10, 2025
Accepts healthy volunteers No
Gender All
Age group 18 Years to 68 Years
Eligibility Inclusion Criteria: 1. Patients with pneumonia that developed Acute Liver Injury 2. Covid 19 pneumonia 3. Patients With acute liver injury only. Exclusion Criteria: 1. Cancer 2. Immunocompromised patients i.e HIV patients and patients who take immunosuppressive medications. 3. Patients who younger than 18 yrs old 4. pregnancy

Study Design

Related Conditions & MeSH terms

Intervention

Other:
• Acute Liver Injury
To evaluate the impact of acute liver injury in patients with pneumonia on hospital stay and outcome.

Locations
Country Name City State
Egypt Faculty Of Medicine Assuit

Sponsors (1)
Lead Sponsor Collaborator
Assiut University

Country where clinical trial is conducted

Egypt, 

Outcome
Type Measure Description Time frame Safety issue
Primary Impact of Acute liver injury due to Pneumonia Analysis the impact of acute liver injury related to patients with pneumonia on hospital stay (measured by days spent in the hospital). From Hospital admission date to Two Months
Secondary Patients with Pneumonia only To evaluate the Patients with Pneumonia either developed acute liver injury or not, On Hospital Stay From Hospital admission date to Two Months
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