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HFNO in Pneumonia Patients Presenting With Acute Hypoxemic Respiratory Failure

Pneumonia Clinical Trial

Official title:
Early-initiated High Flow Nasal Oxygen Therapy in Pneumonia Patients Presenting With Acute Hypoxemic Respiratory Failure

Clinical Trial Summary

High-flow nasal oxygen (HFNO) therapy is an upcoming and beneficial modality for patients with acute hypoxemic respiratory failure (AHRF). To evaluate whether early use of HFNO in pneumonia patients with (AHRF) can reduce the need for invasive ventilation.

Clinical Trial Description

- Pneumonia adults patients (age>18 years) with AHRF were eligible for this study after conventional oxygen therapy failure. - The criteria for diagnosing AHRF were defined as the presence of a respiratory rate (RR) more than 25 breaths/min with SpO2 less than 92%, and/or the arterial oxygen partial pressure (PaO2) to FiO2 ratio less than 300 mmHg while breathing oxygen delivered by a conventional venturi device at a fraction of inspiration oxygen of 0.5 (as per maximum for Venturi mask) administered for at least 60 minutes. Eligible patients were randomized to receive either HFNO or NIV respiratory support throughout the hospitalization period. Randomization was stratified by a laboratory scientist not involved in the study using the technique of shuffled sealed envelopes. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05809089
Study type Interventional
Source Assiut University
Contact
Status Completed
Phase N/A
Start date November 20, 2020
Completion date February 20, 2023
View Details
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