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Pneumonia, Ventilator-Associated clinical trials

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NCT ID: NCT01393431 Terminated - Clinical trials for Ventilator Associated Pneumonia

Futility of Exhaled Breath Condensate pH Measurements in Ventilated Patients in Intensive Care Unit (ICU)

Start date: August 2007
Phase: N/A
Study type: Observational

Measurement of pH in Exhaled breath condensate has been mentioned as a robust variable from lung inflammation. It is non-invasive and reproducible. The investigators measured pH in the water condensed in the trap of expiratory arm of ventilator.In ICU the investigators measured pH in condensed water without interfering with patients treatment. A group of critically ill patients mechanically ventilated due to non pulmonary cause were followed until successful weaning, death or pneumonia. The investigators found that pH did not change along the study and it did not predict worsening condition.

NCT ID: NCT01382446 Completed - Clinical trials for Ventilator Associated Pneumonia

Chlorhexidine Gluconate Oral Care for Adults Experiencing Trauma

Start date: July 2010
Phase: N/A
Study type: Interventional

Examine the use of 0.12% Chlorhexidine Gluconate as an adjunct to current oral care protocol for trauma patients on ventilator support to decrease the incidence of Ventilator Associated Pneumonia and oral bacterial load.

NCT ID: NCT01379157 Completed - Clinical trials for Ventilator Associated Pneumonia

Pharmacodynamics Study of Imipenem in Patients With Ventilator Associated Pneumonia

Start date: November 2011
Phase: Phase 4
Study type: Interventional

Imipenem is a carbapenem antibacterial agent with a broad spectrum of activity against Gram-negative and Gram-positive bacteria. This agent is often used as the last line of therapy for highly resistant Gram negative bacilli nosocomial infections. In common with other beta-lactamase inhibitor, the main pharmacokinetic/pharmacodynamic (PK/PD) index that correlates with the therapeutic efficacy is the time that concentrations in the tissue and serum are above the MIC and administration by continuous infusion is the preferred mode of administration to maximize this parameter. However, in tropical countries, the stability of carbapenem antibiotics is an important consideration when considering continuous infusion. Therefore, prolonged infusion may be a useful mode of administration to maximize bactericidal activity. This study will demonstrate the stability of imipenem in clinical use at room temperature in tropical countries.

NCT ID: NCT01356472 Not yet recruiting - Clinical trials for Pneumonia, Ventilator-Associated

Linezolid Alone or Combined With Carbapenem Against Methicillin-resistant Staphylococcus Aureus (MRSA) in Ventilator-associated Pneumonia

Start date: June 2011
Phase: Phase 4
Study type: Interventional

As previous studies showed that the synergy between linezolid and carbapenem in vitro and in vivo (animal studies), our study is aim to investigate the activity of linezolid, alone and in combination with carbapenem against methicillin-resistant Staphylococcus aureus (MRSA) in ventilator-associated pneumonia (VAP) patients.

NCT ID: NCT01314742 Completed - Clinical trials for Ventilator-associated Pneumonia

Study of Biotene OralBalance Gel for Oral Care in Critically-Ill Mechanically Ventilated Neonates

Start date: May 2010
Phase: Early Phase 1
Study type: Interventional

The goal of this pilot study is to test the hypothesis that mechanically ventilated infants receiving Biotene OralBalance® gel for oral care would have a reduced intubation time compared to infants receiving oral care placebo. This study is also performed to test the feasibility as well the safety of Biotene OralBalance® gel.

NCT ID: NCT01301131 Recruiting - Drug Safety Clinical Trials

Probiotics for Prevention of Ventilator-Associated Pneumonia (VAP)

VAP
Start date: December 2011
Phase: Phase 4
Study type: Interventional

Hospitalized patients with ventilator are randomized to receive fermented dairy product containing L. casei shirota or nothing. The main outcome is development of ventilator-associated pneumonia (VAP)

NCT ID: NCT01294943 Completed - Clinical trials for Ventilator-associated Pneumonia

Evaluating the Effectiveness of the Tongue Cleaner in Critical Patients

Start date: January 2010
Phase: N/A
Study type: Observational

The concern with oral infection and its systemic repercussions is old, many studies have been undertaken to establish this relationship more precisely. One of the areas mouth still little studied in this regard is the colonization of language within this universe of the oral microbiota colonization and how this may affect the general state of health care-dependent individuals. This research aims to evaluate the efficiency of a tongue cleaning device and its potential impacts on infectious patients fully or partially dependent care hospital. Patients admitted to intensive care units and inpatient units will be evaluated, divided into two groups: Study Group (SG) - Patients who receive oral hygiene using the tongue cleaning device, and Control Group (CG) - Patients who are cared for according to the routine of hospital nursing.

NCT ID: NCT01292031 Completed - Clinical trials for Ventilator-associated Bacterial Pneumonia

Trial of Colistin Versus Meropenem in Ventilator-associated Pneumonia (VAP) (CR-GNB)

MagicBullet
Start date: May 2012
Phase: Phase 3
Study type: Interventional

1. To demonstrate that colistin iv. is not inferior to meropenem in empiric treatment of VAP regarding the final point of primary efficacy: mortality in the 28 subsequent days and clinical healing in patients clinically evaluated. 2. To compare the safety of treatment with colistin vs meropenem in VAP. 3. To compare microbiological efficacy of treatment with colistin vs meropenem in VAP

NCT ID: NCT01188122 Completed - Clinical trials for Ventilator Associated Pneumonia

Optimal Endotracheal Cuff Pressure During Hospitalization in Intensive Care Units Using AnapnoGuard 100 System

Start date: April 2008
Phase: N/A
Study type: Interventional

Hospitech Respiration Ltd has developed the AnapnoGuard system, an innovative system intended to enhance optimal endotracheal tube (ETT) cuff inflation, by monitoring carbon dioxide (CO2) in upper airways of mechanically ventilated patients. Optimal ETT cuff inflation will lead to a reduction of complication rate related to mechanical ventilation procedure. This study was design in order to evaluate the feasibility of using the AnapnoGuard system.

NCT ID: NCT01150864 Completed - Acute Lung Injury Clinical Trials

Effects of Airway Conditioning Devices on Ventilator Associated Pneumonia:a Randomized Clinical Trial

AirconVAP
Start date: April 2010
Phase: N/A
Study type: Interventional

The main hypothesis are: 1. Passive and Active-Passive airway conditioning devices reduce the incidence of ventilator associated pneumonia 2. Active-Passive airway conditioning devices reduce the incidence of endotracheal tube obstruction 3. Nurses' workload is reduced with Passive and Active-Passive airway conditioning devices