Healthy Clinical Trial
Official title:
Blood Sampling for Neurochemical and Genetic Testing
This study involves sampling blood from both normal volunteers and patients with diseases
known or suspected to involve body chemicals called catecholamines. The blood will be used
to establish normal values for plasma levels of catecholamines and related neurochemicals;
to test for abnormal neurochemical patterns in patients; and to establish a "bank" of DNA
from normal volunteers and from patients to be used in future studies about possible
alterations of catecholamine-related genes.
Study participants will report to NIH after fasting overnight except for water or
noncaloric, noncaffeinated beverages. They must not have taken Tylenol for at least 5 days.
Blood will then be drawn. DNA will be extracted and stored in the freezer for future
studies.
This project is to allow blood sampling from normal volunteers and patients with dysautonomia, pheochromocytoma, hypertension, or neurogenetic diseases involving catecholaminergic systems. The blood is used to establish normal values for plasma levels of catechols and related neurochemicals; test for abnormal neurochemical patterns in patients; and establish a "bank" of DNA samples from normal volunteers and from patients, to be used in future studies about mutations or polymorphisms of catecholamine-related genes. ;
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