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Population Pharmacokinetics and Dosage Individualization of Oral Pulmonary Vasodilators in PPHN

Persistent Pulmonary Hypertension of the Newborn Clinical Trial

Official title:
Population Pharmacokinetics and Dosage Individualization of Bosentan, Sildenafil and Tadalafil in Persistent Pulmonary Hypertension of the Newborn

Clinical Trial Summary

The use of bosentan, sildenafil and tadalafil in neonates with persistent pulmonary hypertension (PPHN) depends mostly on the empirical experience of pediatricians. Moreover, the recommended dose of those three drugs in treating PPHN remains controversial. Therefore, our aim is to study the pharmacokinetics and pharmacodynamics of bosentan, sildenafil and tadalafil in neonates of PPHN then dose a tailor-made therapeutic regimen.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04379180
Study type Observational
Source Shandong University
Contact
Status Not yet recruiting
Phase
Start date April 26, 2020
Completion date May 30, 2023
View Details
See also
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