Clinical Trial Details
— Status: Completed
Administrative data
| NCT number |
NCT05724251 |
| Other study ID # |
9375 |
| Secondary ID |
|
| Status |
Completed |
| Phase |
|
| First received |
|
| Last updated |
|
| Start date |
October 30, 2021 |
| Est. completion date |
November 30, 2022 |
Study information
| Verified date |
February 2023 |
| Source |
Ataturk University |
| Contact |
n/a |
| Is FDA regulated |
No |
| Health authority |
|
| Study type |
Observational [Patient Registry]
|
Clinical Trial Summary
The goal of this observational study is to compare urine iodine levels of participants
with/without periodontitis.
The main question it aims to answer is there a relationship between iodine levels of urine
and periodontitis.
Participants will give urine samples without any intervention.
Description:
Periodontitis is a chronic, inflammatory disease with a cyclical course with active and
passive periods, which may result in the destruction of gingival fibers, resorption of
alveolar bone, and subsequent tooth loss, by spreading the inflammatory event that started in
the gingiva to the tissues supporting the tooth as a result of the effects of bacteria. The
disease is closely associated with many systemic conditions. These conditions include
diabetes, cardiovascular diseases, respiratory diseases, birth complications, pregnancy,
puberty.
Iodine deficiency is an important public health problem by affecting 10-15% of the population
due to the diseases it causes. Iodine deficiency affects individuals of all ages. When the
daily iodine requirement cannot be met, a group of mental, physical and developmental
retardation symptoms called "Iodine deficiency disorders" (IEB) (Iodine deficiency
disorders-IDD) occur. With the obligatory iodization of table salt, which started in 1998 in
order to eliminate iodine deficiency in Turkey, this problem has been tried to be combated by
switching to iodized salt consumption.
The study material was used by 73 adult individuals who applied to Atatürk University Faculty
of Dentistry, Department of Periodontology for different reasons {1. group (H): periodontally
healthy individuals, group 2 (P): individuals with periodontitis}. Urine samples will be
collected from the participants without any periodontal intervention. Iodine levels in the
urine will be studied.
There are studies in the literature to determine iodine deficiency and to determine the
population periodontal disease status; however, there are no studies evaluating the possible
relationship between iodine deficiency and periodontitis.
The aim of this study; To evaluate the iodine levels detected in the urine samples of
patients with periodontitis by comparing them with healthy controls, and to investigate the
possible role of iodine deficiency in the pathogenesis of periodontitis or a simple marker of
disease activity in the light of these findings.
