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Periodontitis clinical trials

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NCT ID: NCT05195021 Completed - Post-operative Pain Clinical Trials

The Effect of Different Irrigation and Disinfection Methods on Post-operative Pain (PP)

PP
Start date: December 1, 2020
Phase: N/A
Study type: Interventional

Aim: The aim of this study was to examine post-operative pain (PP) severity after conventional irrigation and sonic activation methods, with and without laser disinfection in mandibular molar teeth diagnosed with symptomatic apical periodontitis. Methods: In total, 80 patients with symptomatic apical periodontitis were included in this randomized clinical study. There were four different irrigation and disinfection groups. In group 1, conventional irrigation only was applied. In group 2, EDDY (VDW, Munich, Germany), a sonic irrigation activation system, was applied. In groups 3 and 4, irradiation with a 980-nm diode laser was performed, following irrigation with the conventional method (needle irrigation) and EDDY (VDW) irrigation system, respectively. PP was assessed using a visual analogue scale (VAS). The patients were instructed to record their PP using this scale 8, 24, 48 hours and 7 days post-procedure, in addition to their analgesic intake. A chi-square test, Fisher's exact chi-square test and Fisher-Freeman-Halton exact test were used to assess qualitative data. Inter-group and intra-group parameters were assessed using the Kruskal-Wallis test and Wilcoxon's test at a significance level of p < 0.05 (for both).

NCT ID: NCT05189132 Not yet recruiting - Alzheimer Disease Clinical Trials

Periodonitis and Alzheimer's Disease

Start date: September 1, 2022
Phase:
Study type: Observational

The main objective of this study is to assess whether Periodontal Disease is more prevalent in adult patients diagnosed with Alzheimer's Disease compared to adult patients without Alzheimer's Disease. The secondary objective is to describe and characterize the microbiological and biochemical profile of adult patients diagnosed with Alzheimer's Disease and compare with adult patients without Alzheimer's Disease.

NCT ID: NCT05188196 Recruiting - Periodontitis Clinical Trials

Efficacy of Collagen Sponge Versus Collagen Membrane on Ridge Preservation of Periodontally Compromised Teeth

Start date: April 30, 2022
Phase: N/A
Study type: Interventional

The study aims to evaluate the efficacy of ridge preservation with collagen sponge or collagen membrane in combination with collagenated bovine bone mineral in extraction sockets of periodontally diseased teeth.

NCT ID: NCT05183321 Not yet recruiting - Alzheimer Disease Clinical Trials

Treatment of Periodontal Disease in Patients With Alzheimer's Disease

Start date: June 1, 2024
Phase: N/A
Study type: Interventional

The main objective of this study is to evaluate the effect of periodontal therapy in in subjects with a clinical diagnosis of mild to moderate AD dementia.

NCT ID: NCT05178771 Completed - Periodontitis Clinical Trials

Efficacy of PRF Application on Clinical Parameters and GCF Platelet-derived Growth Factor-BB and Periostin Levels

Start date: March 1, 2022
Phase: N/A
Study type: Interventional

Determine the efficacy of the non-invasive application of PRF on periodontal clinical parameters(pocket reduction) and the levels of PDGF-BB and Periostin in the gingival crevicular fluid.

NCT ID: NCT05174494 Completed - Periodontitis Clinical Trials

Impact of Periodontal Treatment on NT-proBNP Levels

Start date: January 2, 2020
Phase: N/A
Study type: Interventional

In light of the controversy that are already approved but that however still exists regarding the efficacy and influence the management of Periodontitis, the aim of this study was to evaluates, at 6-months follow-up, the post-treatment clinical and serum parameters in patients with periodontitis, treated by either Intensive scaling and root planing (SRP) treatment versus conventional oral hygiene treatment on serum CRP and NT-proBNP levels. The null hypothesis to invalidate was that there were no variations, in relation to clinical and serum CRP and NT-proBNP.

NCT ID: NCT05170880 Completed - Clinical trials for Apical Periodontitis

Effect of Primary Non-surgical Endodontic Therapy on Glycaemic Control in Type 2 Diabetic Patients With Asymptomatic Apical Periodontitis

Start date: February 11, 2019
Phase: N/A
Study type: Interventional

To evaluate the effect of primary non-surgical endodontic therapy on glycaemic control in type 2 diabetic patients with asymptomatic apical periodontitis.After fulfilling the eligibility criteria, patients will be informed about the study and written consent to participate in the study will be acquired from each patient after explaining risks, benefits and alternative treatments.The endodontic treatment for all patients will be performed by a single operator (S.A) following a standardized protocol. The control group will receive no endodontic treatment during the study period. After completion of the study, these patients will be given primary non-surgical endodontic treatment. The patients in control group will be rendered the necessary treatment, if they become symptomatic and/or deny the consent during the course of the study. These patients will be excluded from the study.

NCT ID: NCT05140681 Completed - Periodontitis Clinical Trials

Influence of Flap Position Following FibReORS

Start date: September 1, 2017
Phase: N/A
Study type: Interventional

There is lack of data in literature on keratinized tissue increase after FibReORS in relation to primary flap position. This study has been designed as a split-mouth randomized trial to assess the influence of flap position after FibReORS. 16 patients were recruited and treated. The placement of the flap 2 mm apically to the bone crest instead at the bone level would be a viable approach to increase KT width without delaying wound healing. The extent of post-operative discomfort/pain was not influenced by primary flap position.

NCT ID: NCT05137392 Completed - Periodontitis Clinical Trials

Effect of Novel Oral Hygiene Regimen on Non-surgical Treatment of Stage II and III Periodontitis

Start date: February 1, 2022
Phase: N/A
Study type: Interventional

Achievement of adequate oral hygiene standards is critical to the successful treatment of gum disease. The improvement of the patient's adherence to good oral hygiene is of great importance to obtain the satisfactory treatment outcomes. However, patients' adherence to a proper daily oral hygiene regimen generally remains poor. New electric artificial intelligence powered toothbrushes are able to precisely sense the location of the brushing being performed by the patient and transmit information to the clinician who is able to analyze the data and provide targeted instructions, if needed. This study evaluates whether a novel oral hygiene instruction regimen can provide some additional benefit for periodontal treatment compared with routine oral hygiene instructions.

NCT ID: NCT05129267 Recruiting - Periodontitis Clinical Trials

Evaluation of iPRF With Vitamin C in StageII Grade A Periodontitis

Start date: October 3, 2021
Phase: N/A
Study type: Interventional

Comparing the effect of using vitamin C with injectable PRF as a locally delivered adjunct to scaling and root planing versus scaling and root planing with local delivery of injectable PRF and scaling and root planing alone on the clinical parameters in Stage II Grade A Periodontitis patients.