Gingival Recession Clinical Trial
Official title:
Comparison of the Effects of Different Platelet Concentrates on Palatal Wound Healing
Platelet concentrates used in palatal wound healing have been reported to accelerate wound healing and reduce postoperative patient discomfort. The use of elet platelet rich fibrin '(PRF) in the palatal donor site after FGG surgery has been shown to provide significant benefits in terms of wound healing parameters and postoperative comfort. In a study using a platelet rich plasma (PRP) with a different platelet concentration, PRP was found to accelerate wound healing and shorten the healing time. In another study using titanium-prepared platelet rich fibrin (T-PRF) for palatal wound healing, it accelerated the wound healing process and reached the initial level of soft tissue thickness in the donor region at the end of 6 months. In the literature, there are few studies using platelet concentrates in palatal wound healing and only some concentrates (PRP, PRF, T-PRF) are used. The aim of this study is to compare the effects of injectable platelet rich fibrin (i-PRF), which are autologous fibrin glue (AFG) and injectable platelet concentrates, on palatal wound healing. The findings obtained from this study will contribute to the literature in determining the product and method that will provide optimal postoperative patient comfort and wound healing.
Attached gingiva plays an important role in maintaining periodontal health. In the presence
of inadequate attached gingiva, periodontal tissue inflammation, root sensitivity, root
caries and gingival recessions are caused due to mucogingival stress in the related area and
oral hygiene which is not provided adequately. In such cases, inadequate attached gingival
width should be increased with mucogingival periodontal plastic surgery.
Free gingival graft (FGG) is accepted as the most commonly used mucogingival procedure in
increasing the attached gingival, because of its predictable surgical outcome, simple
technique and its application in large areas of operation. In the free gingival graft
operation, the recipient bed is prepared in the area with insufficient attached gingiva. Free
gingival grafts containing epithelial and connective tissue from the donor area are applied
to this recipient bed in appropriate dimensions . Palatal region is the most preferred donor
site in terms of anatomical advantage, ideal tissue thickness and wide keratinized band
removal. The secondary wound in the donor site after FGG heals in 2-4 weeks and may cause
problems that affect patient comfort such as paresthesia, herpetic lesion, mucocele, bleeding
and pain in the postoperative period. Different products such as hemostatic agents, low-dose
laser treatments, herbal products, ozonated oil, antibacterial / antiseptic agents, bioactive
materials and platelet concentrates have been tested to accelerate wound healing and prevent
these problems. Studies on the determination of the product and method that provide optimal
postoperative patient comfort and wound healing from such products, whose effects on wound
healing are known, are ongoing.
Platelet concentrates used in palatal wound healing have been reported to accelerate wound
healing and reduce postoperative patient discomfort. The use of elet platelet rich fibrin
'(PRF) in the palatal donor site after FGG surgery has been shown to provide significant
benefits in terms of wound healing parameters and postoperative comfort. In a study using a
platelet rich plasma (PRP) with a different platelet concentration, PRP was found to
accelerate wound healing and shorten the healing time. In another study using
titanium-prepared platelet rich fibrin (T-PRF) for palatal wound healing, it accelerated the
wound healing process and reached the initial level of soft tissue thickness in the donor
region at the end of 6 months. In the literature, there are few studies using platelet
concentrates in palatal wound healing and only some concentrates (PRP, PRF, T-PRF) are used.
The aim of this study is to compare the effects of injectable platelet rich fibrin (i-PRF),
which are autologous fibrin glue (AFG) and injectable platelet concentrates, on palatal wound
healing. The findings obtained from this study will contribute to the literature in
determining the product and method that will provide optimal postoperative patient comfort
and wound healing.
In this randomized, controlled clinical study, 36 patients in need of FGG were divided into
three groups. AFG (n=12) or i-PRF (n=12) was applied to donor sites and compared to control
group (n=12). Wound healing with H2O2 test, VAS, MMS scale and LTH index were evaluated on
the 3rd, 7th, 14th day and 1st month. The bleeding status was evaluated on 3rd and 7th days.
Palatal tissue thickness was measured at baseline, 1st month and 3rd month.
AFG and i-PRF have positive effects on the healing process by accelerating wound healing and
reducing postoperative morbidity.
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