Low-Level Laser Effects on Orthodontic Tooth Movement of Periodontally Compromised Patients.

Periodontal Diseases Clinical Trial

Official title:

Low-Level Laser Effects on Orthodontic Tooth Movement of Periodontally Compromised Patients. Clinical and Biochemical Study

Clinical Trial Details — Status: Active, not recruiting

Administrative data

• NCT number: NCT05739838
• Other study ID #: ORTHO-108-6-J
• Status: Active, not recruiting
• Phase: N/A
• Start date: April 1, 2021
• Est. completion date: May 2023

Study information

• Verified date: February 2023
• Source: Faculty of Dental Medicine for Girls
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

To investigate the effect of Low Level Laser therapy on orthodontic tooth movement of periodontally compromised patients by evaluating the rate of orthodontic tooth movement and the level of Osteocalcin in the gingival crevicular fluid.

Description:

Low-Level laser therapy has been reported as an effective adjunct to non surgical periodontal treatment for inflammation control and tissue reparation in patients with periodontitis. Previous studies have shown that application of low-level laser therapy reduced pocket depth and decreased the inflammatory process through regulatory control of inflammatory cytokines level, therefore this study will investigate the effect of low-level laser on the periodontal tissue .Accelerating orthodontic tooth movement is one of the primary demand in orthodontics to prevent side effects as root resorption, caries and decreased patient compliance . Numerous researchers have also studied the use of LLLT in accelerating orthodontic tooth movement and have considered the laser to be effective while others achieved the opposite . Hence, This study is aiming to investigate the effects of LLLT in accelerating tooth movement.

Recruitment information / eligibility

• Status: Active, not recruiting
• Enrollment: 20
• Est. completion date: May 2023
• Est. primary completion date: April 2023
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 25 Years to 35 Years

Eligibility

Inclusion Criteria:

• No systemic disease.
• No history medication (antibiotics and/or anti inflammatory) in the previous 4 months.
• Self motivated patients with acceptable oral hygien.

Exclusion Criteria:

• Previous orthodontic treatment
• Aggressive periodontitis
• Smokers
• pregnant patients

Related Conditions & MeSH terms

• Cancer Metastatic
• Orthodontic Tooth Movement
• Periodontal Diseases

Intervention

Device:
• Biolase ;Low Level Laser
Low Level laser ,940 nm

Locations

Country	Name	City	State
Egypt	Faculty of dental medicine for Girls, AL Azhar University	Cairo

Sponsors (1)

Lead Sponsor	Collaborator
Faculty of Dental Medicine for Girls

Country where clinical trial is conducted

Egypt, 

References & Publications (1)

Ren C, McGrath C, Gu M, Jin L, Zhang C, Sum FHKMH, Wong KWF, Chau ACM, Yang Y. Low-level laser-aided orthodontic treatment of periodontally compromised patients: a randomised controlled trial. Lasers Med Sci. 2020 Apr;35(3):729-739. doi: 10.1007/s10103-019-02923-0. Epub 2019 Dec 12. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Rate of orthodontic tooth movement	Rate of mandibular canine retraction	6 months
Secondary	Osteocalcin level in GCF	Gingival Crevicular Fluid samples will be collected from al target teeth in both groups to detect osteocalcin level after start of orthodontic treatment and at the end of the study	6 months