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Clinical Trial Details — Status: Active, not recruiting

Administrative data

NCT number NCT05739838
Other study ID # ORTHO-108-6-J
Secondary ID
Status Active, not recruiting
Phase N/A
First received
Last updated
Start date April 1, 2021
Est. completion date May 2023

Study information

Verified date February 2023
Source Faculty of Dental Medicine for Girls
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

To investigate the effect of Low Level Laser therapy on orthodontic tooth movement of periodontally compromised patients by evaluating the rate of orthodontic tooth movement and the level of Osteocalcin in the gingival crevicular fluid.


Description:

Low-Level laser therapy has been reported as an effective adjunct to non surgical periodontal treatment for inflammation control and tissue reparation in patients with periodontitis. Previous studies have shown that application of low-level laser therapy reduced pocket depth and decreased the inflammatory process through regulatory control of inflammatory cytokines level, therefore this study will investigate the effect of low-level laser on the periodontal tissue .Accelerating orthodontic tooth movement is one of the primary demand in orthodontics to prevent side effects as root resorption, caries and decreased patient compliance . Numerous researchers have also studied the use of LLLT in accelerating orthodontic tooth movement and have considered the laser to be effective while others achieved the opposite . Hence, This study is aiming to investigate the effects of LLLT in accelerating tooth movement.


Recruitment information / eligibility

Status Active, not recruiting
Enrollment 20
Est. completion date May 2023
Est. primary completion date April 2023
Accepts healthy volunteers Accepts Healthy Volunteers
Gender All
Age group 25 Years to 35 Years
Eligibility Inclusion Criteria: - No systemic disease. - No history medication (antibiotics and/or anti inflammatory) in the previous 4 months. - Self motivated patients with acceptable oral hygien. Exclusion Criteria: - Previous orthodontic treatment - Aggressive periodontitis - Smokers - pregnant patients

Study Design


Intervention

Device:
Biolase ;Low Level Laser
Low Level laser ,940 nm

Locations

Country Name City State
Egypt Faculty of dental medicine for Girls, AL Azhar University Cairo

Sponsors (1)

Lead Sponsor Collaborator
Faculty of Dental Medicine for Girls

Country where clinical trial is conducted

Egypt, 

References & Publications (1)

Ren C, McGrath C, Gu M, Jin L, Zhang C, Sum FHKMH, Wong KWF, Chau ACM, Yang Y. Low-level laser-aided orthodontic treatment of periodontally compromised patients: a randomised controlled trial. Lasers Med Sci. 2020 Apr;35(3):729-739. doi: 10.1007/s10103-019-02923-0. Epub 2019 Dec 12. — View Citation

Outcome

Type Measure Description Time frame Safety issue
Primary Rate of orthodontic tooth movement Rate of mandibular canine retraction 6 months
Secondary Osteocalcin level in GCF Gingival Crevicular Fluid samples will be collected from al target teeth in both groups to detect osteocalcin level after start of orthodontic treatment and at the end of the study 6 months
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