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NCT04268381 Clinical Trial

Oral and Systemic aMMP-8 in Periodontal Disease

Periodontal Diseases Clinical Trial

Official title:
Local And Systemic Levels of aMMP-8 in Gingivitis and Stage 3 Periodontitis

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT04268381
Other study ID # 20-2T/39
Secondary ID
Status Completed
Phase
First received
Last updated
Start date January 20, 2020
Est. completion date March 20, 2020

Study information
Verified date July 2020
Source Aydin Adnan Menderes University
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

Periodontal disease is an inflammatory process that can result in tooth loss and also is considered a modifying factor for systemic health. Matrix metalloproteinase (MMP)-8 is the major collagenase of periodontal tissue breakdown. The aim of the present study is to analyze active (aMMP-8) levels in gingival crevicular fluid (GCF), saliva and serum in the context of new criteria of gingivitis and stage 3 grade C periodontitis.

Recruitment information / eligibility
Status Completed
Enrollment 83
Est. completion date March 20, 2020
Est. primary completion date March 20, 2020
Accepts healthy volunteers Accepts Healthy Volunteers
Gender All
Age group 25 Years to 50 Years
Eligibility Inclusion Criteria:

- systemically healthy and non-smoker individuals aged 25 to 50 years

- having =20 teeth present (except third molars)

- individuals with periodontally healthy, gingivitis and stage 3 periodontitis diagnoses

Exclusion Criteria:

- having any systemic disease

- smoking

- pregnancy or lactation

- using antibiotic or any anti-inflammatory drug or any periodontal treatment within the past 6 months.

Study Design

Related Conditions & MeSH terms

Intervention

Other:
• Biochemical analysis
aMMP-8 is measured by immunofluorometric assay (IFMA).

Locations
Country Name City State
Turkey Aydin Adnan Menderes University Aydin

Sponsors (2)
Lead Sponsor Collaborator
Aydin Adnan Menderes University Giresun University

Country where clinical trial is conducted

Turkey, 

Outcome
Type Measure Description Time frame Safety issue
Primary Oral (GCF and saliva) and serum levels of aMMP-8 in periodontitis and gingivitis aMMP-8 levels through study completion, an average of 4 months
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