Periodontal Diseases Clinical Trial
Official title:
Effect of Non-Surgical Periodontal Therapy on Pregnancy-Related Degree of Gingival Inflammation and Stress Markers
Background: The purpose of the present study is to research whether stress scale scores alter
with relationship to gingival inflammation and examine the impact of non-surgical periodontal
therapy during pregnancy on the levels of cytokines in gingival crevicular fluid (GCF) and on
salivary stress-related hormones.
Methods: 30 non-pregnant (control group) and 30 pregnant women (test group) who fulfilled the
study inclusion criteria were chosen. The participants with moderate/severe gingivitis were
included. Clinical data and samples of GCF and salivary were collected at baseline and after
periodontal therapy. The levels of cytokines interleukin-1 beta (IL-1β) and IL-10, and
concentration of salivary chromogranin A (Cg A) hormone were analyzed by enzyme-linked
immunosorbent assay kits.
Periodontal clinical measurements and periodontal treatment were applied by a previously
trained and calibrated examiner. Clinical parameters measurements including; probing pocket
depths (PPD; the distance from the gingival margin to the base of the gingival sulcus),
clinical attachment level (CAL), full mouth gingival index (GI)21 and plaque index (PI)20
scores using a periodontal probe were registered following saliva and GCF sample collection.
Then, non-surgical periodontal therapy (NPT) consisted of scaling, root planning, and oral
hygiene instruction was applied. Clinical measurements, recruitment of GCF, and saliva
samples were repeated after three weeks.
Gingival Crevicular Fluid and Saliva Sample Collection Selected anterior teeth for GCF
sampling were isolated from saliva using cotton rolls, a gentle stream of air was conducted
parallel to the root surface for 5 to 10 seconds to dry the area.
The periopaper strips were gently inserted into the gingival crevice until resistance was
felt and were left in place for 30 s and were collected from mesio-buccal sulcus of teeth in
the anterior region of each patient (two samples per patient and per visit). The samples
containing blood were discarded and were placed in sterile Eppendorf tubes and were stored at
-20°C until the assay procedure.
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