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Surgical Site Infection in Perforated Appendicitis After Peritoneal Lavage With Super-oxidised Solution — PLaSSo  

Perforated Appendicitis Clinical Trial

Official title:
Incidence of Surgical Site Infection in Perforated Appendicitis After Peritoneal Lavage With Super-oxidised Solution: A Randomised Double-blind, Placebo-controlled Trial

Clinical Trial Summary

This study is to evaluate the effectiveness of peritoneal lavage with super-oxidised solution in reducing surgical site infection after open surgery for perforated appendicitis.

Clinical Trial Description

Open appendicectomy for perforated appendicitis is associated with significant morbidity from surgical site infection. The standard practice is to perform peritoneal and wound lavage using normal saline solution. The investigators propose the use of superoxidized solution for peritoneal and wound lavage to decrease the incidence of surgical site infection. Superoxidized solutions contain hypochlorous acid (HOCl) which has bactericidal properties. The reactive oxygen species that is produces damages cell wall membrane of unicellular organisms, however remains safe when in contact with human or animal tissue. It is commonly used for topical treatment of wounds. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04512196
Study type Interventional
Source Hospital Queen Elizabeth, Malaysia
Contact
Status Completed
Phase N/A
Start date September 9, 2020
Completion date April 11, 2022
View Details
See also
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