Hyperbilirubinemia in Acute Appendicitis as a Predictor of Perforation

Perforated Appendicitis Clinical Trial

Official title:

Prospective Study Comparing Hyperbilirubinemia, CRP, White Blood Cell Count, and Other Clinical Parameters for the Preoperative Diagnosis of Perforated Acute Appendicitis

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00528138
• Other study ID #: HLS-0045-07-07
• Status: Completed
• Phase: N/A
• First received: September 10, 2007
• Last updated: November 9, 2009
• Start date: October 2007
• Est. completion date: September 2008

Study information

• Verified date: November 2009
• Source: Cirujanos la Serena
• Contact: n/a
• Is FDA regulated: No
• Health authority: Chile: Instituto de Salud Pública de Chile
• Study type: Observational

Clinical Trial Summary

It has recently been published that hyperbilirubinemia is a reliable marker for the preoperative diagnosis of perforated acute appendicitis.

The investigators believe, based on their own previous publications, that C-reactive protein (CRP) with or without a white blood cell count and some other clinical parameters, are more specific markers for the preoperative diagnosis of perforated acute appendicitis.

The purpose of this study is to prospectively compare the specificity and sensitivity of hyperbilirubinemia CRP, white blood cell count and other clinical parameters for the preoperative diagnosis of acute appendicitis.

Description:

• Previously validated appendicitis score

• Time from onset of symptoms to diagnosis and to surgery

• Laboratory values: WBC, CRP, liver function test

• SIRS values

• Preoperative and postoperative diagnosis

• Length of hospital stay

• Postoperative complications

• Biopsy results

Recruitment information / eligibility

• Status: Completed
• Enrollment: 132
• Est. completion date: September 2008
• Est. primary completion date: September 2008
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 15 Years and older

Eligibility

Inclusion Criteria:

• Patients scheduled for appendectomies for acute appendicitis at the emergency unit of our institution

• Patients older than 15 years of age to 100 years of age

Exclusion Criteria:

• Appendectomy performed incidentally or for other indications

• Patients younger than 15 years of age

• Alcoholism

• A history of viral hepatitis

• Gilbert's disease

• Dubin Johnson syndrome

• BRIC (benign recurrent intra-hepatic cholestasis) and other documented biliary

• Hemolytic or liver diseases associated with hyperbilirubinaemia

Study Design

Observational Model: Cohort, Time Perspective: Prospective

Related Conditions & MeSH terms

• Appendicitis
• Hyperbilirubinemia
• Perforated Appendicitis

Intervention

Other:
• Laboratory Test
CRP, white blood cell count, hepatic function tests

Locations

Country	Name	City	State
Chile	Hospital De La Serena - Emergency Unit	La Serena	IV Region

Sponsors (1)

Lead Sponsor	Collaborator
Cirujanos la Serena

Country where clinical trial is conducted

Chile, 

External Links

•   This study has been published in the September/October Number of the Indian Journal of Surgery (Indian J Surg 2009; 71:265-272)