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Pediatrics clinical trials

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NCT ID: NCT06449157 Not yet recruiting - Anesthesia Clinical Trials

Chocolate or Sevoflurane: Use of Parosmia to Facilitate More Cooperative Inhalation Inductions in Children

Start date: June 2024
Phase: N/A
Study type: Interventional

Children undergoing surgery and anesthesia are often negatively impacted by anxiety and fear in the preoperative period. Routine inhalational anesthetic induction is a unique aspect of pediatric anesthesia. Inhalation inductions are usually initiated with sevoflurane with or without nitrous oxide. While less pungent than other volatile agents, sevoflurane at high concentrations and flows used for inhalation inductions still causes children to often repel from the smell. This can lead to an unpleasant interaction and cause heightened anxiety for any subsequent procedures. Olfactory senses are processed in the hippocampus and amygdala and tied to emotion and memory. Parosmia is the distortion of smell perception which can utilized to the pediatric anesthesiologists advantage. It has been demonstrated that using this phenomenon, the anesthesiologist can induce a better smell for the child leading to improved cooperation during an inhalation induction. However, limitations of this study include lack of randomization, small sample size, and use of a nominal scale of yes or no for face mask acceptance. The investigators identified no other studies to validate this potentially powerful tool to optimize anesthetic induction for pediatric patients. The overall objective of this pilot randomized trial is to determine the feasibility of parosmia during inhalation inductions to decrease perioperative stress for children and provide key pilot data to power a larger study to determine effectiveness of parosmia during inhalation inductions to decrease perioperative stress for children and provide key pilot data to power a larger study to determine effectiveness of parosmia.

NCT ID: NCT06431802 Not yet recruiting - Critical Illness Clinical Trials

Construction and Application of the Visualization Training Platform Based on a Multimodal Standardized Dataset for Pain Assessment in Critically Ill Children

Start date: June 2024
Phase: N/A
Study type: Interventional

The goal of this clinical trial is to learn if the visualization training platform based on a multimodal standardized dataset for pain assessment in critically ill children is applicable for pain assessment training. The main questions it aims to answer are: 1. Does pain assessment training with a visualization training platform based on a multimodal standardized dataset for pain assessment in critically ill children improve participants' knowledge level of pain assessment? 2. Does pain assessment training with a visualization training platform based on a multimodal standardized dataset for pain assessment in critically ill children improve participants' skill level of pain assessment? Researchers will compare a visualization training platform based on a multimodal standardized dataset for pain assessment in critically ill children to on-site lesson to see how well the platform intervention can be applied to pain assessment training. Participants will: 1. Use the visualisation platform or receive on-site lesson for pain assessment training every week for 1 month 2. Test before and 1 month after the start of the study

NCT ID: NCT06428175 Not yet recruiting - Pediatrics Clinical Trials

Hospital-to-Home Care Transition Interventions (H2H-CTI) Children/Youth With Special Health Care Needs (CYSHCN)

H2H-CYSHCN
Start date: March 2025
Phase: N/A
Study type: Interventional

Aim 1: Compare the effectiveness of focused dose vs extended dose hospital-to-home care transition interventions (H2H-CTI) on health service use and parent-reported confidence for hospitalized CYSHCN. Aim 2: Compare the effectiveness of focused and extended dose H2H-CTI among vulnerable CYSHCN subgroups. Hypothesis: Both H2H-CTI arms will improve primary outcomes more for CYSHCN with higher versus lower clinical complexity; while extended H2H-CTI will better mitigate racial/ethnic outcome disparities than focused H2H-CTI. Aim 3: Evaluate implementation context, processes, and mechanisms via a multi-phase mixed methods study design.

NCT ID: NCT06426394 Not yet recruiting - Pediatrics Clinical Trials

Effect of Positive End-expiratory Pressure on Gastic Residual Volume

Start date: May 20, 2024
Phase:
Study type: Observational [Patient Registry]

This study was designed as a prospective observational study.

NCT ID: NCT06235125 Not yet recruiting - Osteosarcoma Clinical Trials

Safety and Feasibility of Intraoperative Visualization With Cytalux in Children

Cytalux
Start date: January 20, 2024
Phase: Phase 1
Study type: Interventional

Pediatric subjects aged 6-17 with biopsy confirmed cancer and imaging findings suspicious for pulmonary metastatic disease scheduled to undergo pulmonary metastasectomy via and open or minimally invasive approach.

NCT ID: NCT05815563 Not yet recruiting - Anesthesia, Local Clinical Trials

Validation of Peripheral Perfusion Index in Predicting Successful Supraclavicular Brachial Plexus Block in Pediatrics

Start date: September 2023
Phase:
Study type: Observational

Few data are available for the PI as a tool for evaluation of peripheral block success in pediatric patients. Furthermore, there is currently no cut-off value defined for the accuracy of the PI in the detection of successful block.

NCT ID: NCT04087070 Not yet recruiting - Blood Pressure Clinical Trials

Blood Pressure Estimation Using Noninvasive Biosignals During Pediatric Anesthesia

Start date: September 28, 2020
Phase:
Study type: Observational

The aim of this study is to estimate blood pressure in pediatric patients using a non-invasive electrocardiogram (ECG), photoplethysmograph (PPG), and an accelerometer on the chest.

NCT ID: NCT03812913 Not yet recruiting - Pediatrics Clinical Trials

Neuropsychological Assessment of Children and Adolescents With Turner Syndrome

ENEAST
Start date: February 2019
Phase:
Study type: Observational

Turner syndrome (TS) is a rare chromosomal disorder characterized by partial or complete loss of one of the X chromosomes that affects about one in every 2000 female babies born. These young patients described difficulties making friends, understanding others' emotions and intentions, and controlling their own emotions. Difficulties in these domains could led to social withdrawal, to reduced social skills and could have a significant impact on self esteem and mental health as well as on long-term academic and social functioning in affected individuals. The purpose of this project is to identify functional and dysfunctional cognitive and socio-cognitive abilities in these young patients which could account social difficulties described by some of them and their family. To this end, 35 girls with TS and 35 girls with isolated growth hormone deficiency and normal cerebral MRI will be recruited. Subjects will be 7 to 16 years and 11 months of age. Socio-cognitive and cognitive functions will be assessed with neuropsychological and experimental tasks. Questionnaires completed by patient, parents or teacher, will evaluate social and behavioral functioning.

NCT ID: NCT01682122 Not yet recruiting - Blood Pressure Clinical Trials

Frequency and Persistence of Wide Pulse Pressure in the Neonatal Population

Start date: August 2012
Phase: N/A
Study type: Observational

Wide Pulse Pressure is frequently present in the normal, full-term neonatal population. This study will evaluate the frequency and persistence of wide pulse pressure in the neonatal population. Using a prospective study design in the Regular newborn and Observation nurseries of SIUH, North site. Healthy newborns that are between 0-72 hrs of age will have their blood pressures measured using the oscillometric method. This data will offer insight into whether the presence of wide pulse pressure in otherwise healthy newborn infants warrants further cardiovascular evaluation

NCT ID: NCT01678066 Not yet recruiting - General Anesthesia Clinical Trials

A Prospective Study to Bilaterally Compare a Non-Invasive Cardiac Output Monitor

Start date: September 2012
Phase: N/A
Study type: Observational

Study hypothesis: The Cardiotronic ICON non-invasive cardiac output monitor gives accurate information when placed on a patient's Right or Left side. Summary: To simultaneously compare physiologic data collected from two non-invasive cardiac output monitors placed bilaterally on pediatric patients undergoing general anesthesia. The FDA approved Cardiotronic ICON non-invasive cardiac output monitor has been validated by the manufacturer in pediatric and adult patients with leads placed on the left side. However, sometimes the surgical site and/or patient position precludes placement of the monitor leads on the left side. In such situations it would be useful to know whether placement of the monitor's leads on a patient's right side gives accurate cardiac output data. We will prospectively collect, and compare, simultaneous physiologic data for all enrolled children using two monitors, one on the patient's right side and one on the patient's left side.