Patients With Acute Exacerbation of Chronic Obstructive Pulmonary Disease Clinical Trial
Official title:
Registry on the EXperience of Extracorporeal CO2 Removal in Intensive Care Units
Investigators will aim to conduct an observational study in order to assess very thoroughly
all patients implanted by Extracorporeal carbon dioxide removal (ECCO2R) in 10 critical care
units of Paris and its surburb (APHP, Assistance Publique des hôpitaux de Paris).
Secondary objectives will be:
1. to assess efficacy and safety of ECCO2R,
2. to compare the data issue from the registry to others studies assessing the same
population and to other centers and
3. to compare the different ECCOR devices in terms of efficacy and adverse events.
The registry will be conducted prospectively during 2 years in 10 ICUs of l'APHP on behalf on
the CEDIT. The 10 centers are : (1) ICU of l'hôpital europeén Georges Pompidou, (2) ICU of
l'Hôpital Louis Mourier, (3) ICU of l'Hôpital de Bicêtre, (4) ICU of GHPS, (5) Respiratory
ICU of GHPS, (6) ICU of l'Hôpital Lariboisière (7) ICU of l'Hôpital Cochin (8) ICU of
l'Hôpital Saint-Antoine (9)ICU of l'Hôpital Henri Mondor and (10) ICU of l'Hôpital Tenon.
The primary outcome will be the number of patients implanted by ECCO2R monthly in each center
during the 2 years period study.
Secondary outcomes will be ICU-mortality, invasive ventilation duration, non invasive
ventilation duration, ICU duration, modalities of ventilation at the ICU discharge,
hemorragic complications due to the ECCOR device, thrombotic complications due to ECCO2R
device, intravascular hemolysis due to ECCO2R device, duration of ECCO2R, adjunct therapy to
ECCO2R and reasons of ECCO2R discontinuation.
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