Patients Receiving Antimicrobial Therapy Clinical Trial
Official title:
Impact of Infectious Diseases Specialists on the Appropriateness of Antimicrobial Therapy in Surgical and Medical Wards: a Multicenter Randomized Controlled Trial.
CONTEXT: Antibiotics are frequently used in hospital but the appropriateness of
prescriptions ranged between 25-50%. The intervention of infectious disease specialists
(IDS) could improve the appropriateness of prescriptions and reduce their use. The impact of
IDS has not been yet fully estimated using a randomized trial to compare the quality of care
of patients who will benefit of the intervention.
OBJECTIVES: To show using a randomized trial that patients with IDS advice will receive more
appropriate antimicrobial therapy but less exposure to antibiotics, as compared to patients
who will not receive IDS advice.
METHODS: Prospective randomized trial comparing antibiotic exposure and appropriateness of
prescriptions in two groups of patients:
- Control group: antibiotic prescriptions will be initiated and managed by the attending
physicians
- Intervention group: antibiotic prescriptions will be systematically evaluated by the
IDS and changed if judged necessary by the attending physicians, following IDS' advice.
STUDY PROCESS: The study will took place in 4 university hospitals. Two medical or surgical
wards will participate by hospital. For each ward, the period of the study will be 2 x 4
weeks.Total duration of the study: 12 months.
n/a
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Outcomes Assessor), Primary Purpose: Treatment