Parkinson's Disease Clinical Trial
Official title:
The Effect of Speed of Processing Training on Pedestrian Behavior in Patients With Parkinson's Disease and Healthy Older Adults
The purpose of this prospective, within-subject randomized cross-over design study is to determine if a computer training program (Speed of Processing Training - SOPT) improves safe pedestrian behavior in patients with Parkinson's disease and in healthy older adults in a virtual reality pedestrian environment. Pedestrian injury poses significant risk to healthy older adults and patients with Parkinson's disease. Several age-related changes, including slowing of visual processing speed, increase risky pedestrian behavior. This study will determine if SOPT improves pedestrian behavior in patients with Parkinson's disease and healthy older adults and evaluate the persistence of the SOPT training effects.
Pedestrian injury poses significant risk to healthy older adults and patients with
Parkinson's disease. Several age-related changes, including slowing of visual processing
speed, increase risky pedestrian behavior. Persons with Parkinson's disease (PD) are at even
higher risk of pedestrian injury due to motor and non-motor symptoms. Parkinson's disease
(PD) is a progressive neurodegenerative disorder characterized by motor symptoms including
slowness, tremor, stiffness, and balance problems. Visual processing speed abnormalities,
anxiety, and cognitive problems are common non-motor symptoms.
The Useful Field of View (UFOV®) test is a measure of visual processing speed. The UFOV® test
is performed on a touch-screen computer that displays objects in the central and peripheral
visual fields for brief durations. Successful performance on the test requires integration of
visual sensory information and higher-order cognitive processing. Our own research has shown
that the UFOV® test performance correlates with pedestrian behavior in PD patients.
Speed of Processing Training (SOPT) is a computer-based training that uses visual exercises
to improve cognitive processing. The training involves identifying and localizing visual
information quickly in increasingly demanding visual displays. SOPT has been demonstrated to
improve performance on the UFOV test in healthy older adults and PD patients. It is
hypothesized that SOPT training will improve pedestrian safety in healthy older adults and PD
patients.
In the proposed study, we will use a within-subject, randomized, controlled, cross-over
design to evaluate if a computer training program (Speed of Processing Training - SOPT)
improves safe pedestrian behavior in patients with Parkinson's disease and in healthy older
adults in a virtual reality pedestrian environment and if the effects of training persist
long-term.
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