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Clinical Trial Details — Status: Completed

Administrative data

NCT number NCT02824341
Other study ID # CHU-0270
Secondary ID 2015-A00761-48
Status Completed
Phase N/A
First received June 24, 2016
Last updated March 14, 2018
Start date October 2015
Est. completion date October 2017

Study information

Verified date March 2018
Source University Hospital, Clermont-Ferrand
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

Up to 60% of Parkinson's Disease (PD) patients suffer from REM sleep behavior disorder (RBD), a parasomnia. This disorder is thought to be related to a dysfunction of limbic system and brainstem.

Impulse control disorders (ICD) are found in about 14% of PD patients taking dopaminergic drugs. These disorders are thought to be related to a dysfunction of meso-cortico-limbic pathways which belong to the so-called "reward system".

A strong link was found between these two disorders and therefore the investigators believe that RBD is associated with impaired reward system.

The main objective of this study is to evaluate differences in brain activation between PD patients with and without RBD.

The investigators hypothesize that PD patients with RBD have a more severe dysfunction of the reward system (hypoactivation of the meso-cortico-limbic pathway) than patients without RBD, explaining their susceptibility to ICD when exposed to high doses of dopaminergic treatment.


Description:

Type of study: Prospective, case control study.

Number of centers: 2 (Clermont-Ferrand and Vichy)

Patients :

The study will be performed in 75 subjects (25 PD patients with RBD, 25 PD patients without RBD and 25 healthy volunteers, age-and sex-matched without any contraindications to perform an MRI)

Study Performance :

During the first visit (J0, inclusion visit, 3 hours), each subject will perform a clinical and neurological examination (MDS-Unified Parkinson Disease Rating scale (MDS-UPDRS)) and neuropsychological assessment (depression by the Beck Depression Inventory (BDI); apathy by the Lille Apathy Rating Scale (LARS), impulsivity by the Urgency, lack of Premeditation, lack of Perseverance, Sensation Seeking scale (UPPS)) Eligible patients will be welcomed in a subsequent visit at the MRI department for the functional MRI (J0+1week, 1 hour). This session will be of about 45 minutes. The reward system was explored using an experimental task during functional Magnetic Resonance Imaging (fMRI). The name of this task is the"monetary incentive delay task".


Recruitment information / eligibility

Status Completed
Enrollment 104
Est. completion date October 2017
Est. primary completion date June 2017
Accepts healthy volunteers Accepts Healthy Volunteers
Gender All
Age group 45 Years to 80 Years
Eligibility Inclusion Criteria:

- Parkinson's disease (UK Parkinson's Disease Society Brain Bank Criteria)

- men or women 45 to 80 years old

- diagnosis of RBD made with polysomnographic recording

Exclusion Criteria:

- Previous history of psychosis or psychiatric disease

- History of stroke or vascular lesion on MRI.

- pregnant women

Study Design


Intervention

Device:
fMRI


Locations

Country Name City State
France CHU Clermont-Ferrand Clermont-Ferrand

Sponsors (2)

Lead Sponsor Collaborator
University Hospital, Clermont-Ferrand Neurodis Foundation

Country where clinical trial is conducted

France, 

Outcome

Type Measure Description Time frame Safety issue
Primary BOLD signal variation in each region of interest BOLD signal variation in each region of interest (ventral tegmental area, accumbens nucleus, limbic cortex, prefrontal cortex) at the time of realisation of fMRI. at week 1
Secondary Reaction time to the task at week 1
Secondary Performance score to the task at week 1
Secondary Hoehn et Yahr score at week 1
Secondary The Unified Parkinson Disease Rating scale (MDS-UPDRS) score at week 1
Secondary The Beck Depression Inventory score at week 1
Secondary The Lille Apathy Rating Scale score at week 1
Secondary The impulsivity score by the Urgency at week 1
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