Parkinson's Disease Clinical Trial
Official title:
Does Cognitive Impairment Affect Rehabilitation Outcome in Parkinson's Disease?
In order to explore the question how an intensive, goal-based and aerobic rehabilitation treatment, addressed to act on motor and mental aspects, affects motor and functional symptoms in PD patients with normal cognition and with different level of cognitive impairment. Hypothesis is that a specific rehabilitation program based on motor-cognitive training and repetition, can affect positively the rehabilitation outcome regardless of baseline cognitive profile.
Objective: This study is aimed to evaluate the impact of cognitive decline on rehabilitation
outcomes in Parkinson's disease (PD). While cognitive status is considered as a determinant
of rehabilitation outcome, no studies about this issue have been performed before.
Methods: 438 PD patients hospitalized for a 4-weeks Multidisciplinary Intensive
Rehabilitation Treatment (MIRT) were enrolled. According to Mini Mental State Examination
(MMSE), patients were divided into: normal cognition (MMSE 27-30), mild cognitive impairment
(MMSE 21-26), moderate or severe cognitive impairment (MMSE ≤ 20). According to Frontal
Assessment Battery (FAB), subjects were divided into patients with normal (FAB ≥ 13.8) and
pathological (FAB < 13.8) score. The outcomes measures were: Unified Parkinson's Disease
Rating Scale (UPDRS), Berg Balance Scale (BBS), Timed Up and Go Test (TUG), Six Minutes
Walking Test (6MWT), Parkinson's Disease Disability Scale (PDDS).
;
Allocation: Non-Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Investigator), Primary Purpose: Treatment
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