Treatment of Orthostatic Intolerance in Patients With Parkinson's Disease Using Midodrine

Parkinson's Disease Clinical Trial

Official title:

Treatment of Orthostatic Intolerance in Patients With Parkinson's Disease Using Midodrine

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT02365012
• Other study ID #: 01482
• Status: Recruiting
• Phase: N/A
• First received: February 10, 2015
• Last updated: August 25, 2015
• Start date: April 2014

Study information

• Verified date: August 2015
• Source: Philadelphia Veterans Affairs Medical Center
• Contact: James Morley, MD/Ph.D.
• Phone: 215-823-5934
• Is FDA regulated: No
• Health authority: United States: Federal Government
• Study type: Interventional

Clinical Trial Summary

This study will evaluate whether treatment with the α1-agonist, midodrine, reduces subjective orthostatic lightheadedness as measured by the Non-Motor Symptoms Scale for Parkinson's Disease (NMSS) questionnaire, in patients with (positive control group, OH) or without documented orthostatic hypotension(orthostatic intolerance, OI). It will also demonstrate the effect of treatment with an α1-agonist, midodrine, on beat-to-beat blood pressure and heart rate response during Valsalva maneuver (measured by Continuous Non-invasive Arterial Pressure, CNAP) in patients with OI or OH and evaluate the relationship to symptom improvement.

Description:

This will be a cross-over study where participants with OI will be randomized to initially receive midodrine or placebo then crossed over to the opposite treatment after three weeks (2 weeks on midodrine or placebo plus one week wash out period). The control group will consist of participants with OH and PD being treated with midodrine. Basic demographic data including will be collected from the medical record of each participant after consent. At each study visit, each participant will undergo traditional measurement of blood pressure and heart rate as well as measurement of beat-to-beat blood pressure and heart rate using CNAP™ during valsalva maneuver and in response to standing for 5 minutes after sitting. Symptoms of orthostatic intolerance will be measured during the study visit using Domain 1 of the Non-Motor Symptoms Scale for Parkinson's Disease (NMSS). At the initial study visit, participants will also be administered first dose of midodrine or placebo. Supine sitting, and standing systolic and diastolic blood pressure and pulse rates will be measured immediately before and 1 hour after the administration of drug or placebo. This blood pressure monitoring process will take place at each of the four study visits.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 50
• Est. primary completion date: June 2017
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Both
• Age group: 22 Years to 89 Years

Eligibility

Inclusion Criteria:

1. Patients with a diagnosis of idiopathic Parkinson's Disease

2. Those patients with measured orthostatic hypotension will be included in the positive control group

3. Those patients without measurable orthostatic hypotension who have symptoms of lightheadedness on standing will be included in the study group

Exclusion Criteria:

1. Diagnosis of degenerative parkinsonian syndromes other than idiopathic Parkinson's Disease

2. Inability to stand independently and remain standing for 5 minutes

3. Cognitive impairment that is significant enough to affect the ability of the patient to provide informed consent or to reliably report orthostatic symptoms

4. Patients with a pacemaker will also be excluded because the study is measuring heart rate responses which could potentially be altered by a pacemaker

5. Because this study will be using a drug that can affect blood pressure, those patients with a standing BP of > 139/90 and heart rate <60 will be excluded

6. Because this study will be using a drug that can affect supine hypertension, those patients with a supine BP of >139/90 and heart rate <60 will be excluded

7. Current treatment with other drugs for orthostatic hypotension such as fludrocortisone

8. Patients on phenylephrine, pseudoephedrine, ephedrine, phenylpropanolamine, dihydroergotamine

9. Patients with acute or chronic renal failure (GFR <60)

10. Patients with a history of pheochromocytoma, urinary retention, severe cardiac disease, history of congestive heart failure, diabetes, narrow-angle glaucoma, arrhythmias, bradycardia, severe hyperthyroidism, severe difficult urination (due to urinary retention or enlarged prostate)

11. Pregnant or breast-feeding women.

12. Women of childbearing potential with no effective contraceptive method of birth control and/or who are unwilling or unable to be tested for pregnancy.

13. Women of childbearing potential must have a confirmed negative pregnancy test at screening and randomization visits. They must use an effective contraceptive method throughout the study, and agree to repeat urine pregnancy test at designated visits. The applied methods of contraception have to meet the criteria for a highly effective method of birth control (condoms, FDA approved oral contraceptives, patches, injections, rings, IUD).

14. Patients with known drug allergy or hypersensitive to midodrine.

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Treatment

Related Conditions & MeSH terms

• Orthostatic Intolerance
• Parkinson Disease
• Parkinson's Disease

Intervention

Drug:
• Midodrine
Crossover intervention comparing midodrine to placebo for subjects with orthostatic intolerance

Locations

Country	Name	City	State
United States	PVAMC	Philadelphia	Pennsylvania

Sponsors (1)

Lead Sponsor	Collaborator
Philadelphia Veterans Affairs Medical Center

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	NMSS Domain I (improvement in symptoms of lightheadedness when standing)	improvement in symptoms of lightheadedness when standing	7 weeks	No
Secondary	Valsalva response (Beat-to-beat blood pressure and heart rate variation during Valsalva maneuver)	Beat-to-beat blood pressure and heart rate variation during Valsalva maneuver	7 weeks	No