Parkinson's Disease Clinical Trial
Official title:
Peripheral and Central Postural Disorders in the Elderly
There is emerging research detailing the relationship between balance/gait/falls and
cognition. Imaging studies also suggest a link between structural and functional changes in
the frontal lobe (a region commonly associated with cognitive function) and mobility. People
with Parkinson's disease have important changes in cognitive function that may impact
rehabilitation efficacy. Our underlying hypothesis is that cognitive function and frontal
lobe connections with the basal ganglia and brainstem posture/locomotor centers are
responsible for postural deficits in people with Parkinson's disease and play a role in
rehabilitation efficacy. The purpose of this study is to 1) determine if people with
Parkinson's disease can improve mobility and/or cognition after partaking in a cognitively
challenging mobility exercise program and 2) determine if cognition and brain circuitry
deficits predict responsiveness to exercise rehabilitation.
Design: This study is a randomized cross-over controlled intervention to take place at a
University Balance Disorders Laboratory. The study participants will be people with
Parkinson's disease who meet inclusion criteria for the study. The intervention will be 6
weeks of group exercise (case) and 6 weeks of group education (control). The exercise is a
cognitively challenging program based on the Agility Boot Camp for people with PD. The
education program is a 6-week program to teach people how to better live with a chronic
disease. The primary outcome measure is the MiniBESTest and the secondary outcomes are
measures of mobility, cognition and neural imaging.
Discussion: The results from this study will further our understanding of the relationship
between cognition and mobility with a focus on brain circuitry as it relates to
rehabilitation potential.
n/a
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT02915848 -
Long-term Stability of LFP Recorded From the STN and the Effects of DBS
|
||
| Recruiting |
NCT03648905 -
Clinical Laboratory Evaluation of Chronic Autonomic Failure
|
||
| Terminated |
NCT02688465 -
Effect of an Apomorphine Pump on the Quality of Sleep in Parkinson's Disease Patients (POMPRENELLE).
|
Phase 4 | |
| Completed |
NCT05040048 -
Taxonomy of Neurodegenerative Diseases : Observational Study in Alzheimer's Disease and Parkinson's Disease
|
||
| Active, not recruiting |
NCT04006210 -
Efficacy, Safety and Tolerability Study of ND0612 vs. Oral Immediate Release Levodopa/Carbidopa (IR-LD/CD) in Subjects With Parkinson's Disease Experiencing Motor Fluctuations
|
Phase 3 | |
| Completed |
NCT02562768 -
A Study of LY3154207 in Healthy Participants and Participants With Parkinson's Disease
|
Phase 1 | |
| Completed |
NCT00105508 -
Sarizotan HC1 in Patients With Parkinson's Disease Suffering From Treatment-associated Dyskinesia
|
Phase 3 | |
| Completed |
NCT00105521 -
Sarizotan in Participants With Parkinson's Disease Suffering From Treatment Associated Dyskinesia
|
Phase 3 | |
| Recruiting |
NCT06002581 -
Repetitive Transcranial Magnetic Stimulation(rTMS) Regulating Slow-wave to Delay the Progression of Parkinson's Disease
|
N/A | |
| Completed |
NCT02236260 -
Evaluation of the Benefit Provided by Acupuncture During a Surgery of Deep Brain Stimulation
|
N/A | |
| Completed |
NCT00529724 -
Body Weight Gain, Parkinson, Subthalamic Stimulation
|
Phase 2 | |
| Active, not recruiting |
NCT05699460 -
Pre-Gene Therapy Study in Parkinson's Disease and Multiple System Atrophy
|
||
| Completed |
NCT03703570 -
A Study of KW-6356 in Patients With Parkinson's Disease on Treatment With Levodopa-containing Preparations
|
Phase 2 | |
| Completed |
NCT03462680 -
GPR109A and Parkinson's Disease: Role of Niacin in Outcome Measures
|
N/A | |
| Completed |
NCT02837172 -
Diagnosis of PD and PD Progression Using DWI
|
||
| Not yet recruiting |
NCT04046276 -
Intensity of Aerobic Training and Neuroprotection in Parkinson's Disease
|
N/A | |
| Recruiting |
NCT02952391 -
Assessing Cholinergic Innervation in Parkinson's Disease Using the PET Imaging Marker [18F]Fluoroethoxybenzovesamicol
|
N/A | |
| Active, not recruiting |
NCT02937324 -
The CloudUPDRS Smartphone Software in Parkinson's Study.
|
N/A | |
| Completed |
NCT02874274 -
Vaccination Uptake (VAX) in PD
|
N/A | |
| Terminated |
NCT02894567 -
Evaluation of Directional Recording and Stimulation Using spiderSTN
|
N/A |