Parkinson's Disease Clinical Trial
Verified date | July 2016 |
Source | China Medical University Hospital |
Contact | n/a |
Is FDA regulated | No |
Health authority | Taiwan: Research Ethics Committee |
Study type | Interventional |
We aim to investigate the higher level mechanism of gait disorders in PD patients by ambulatory recording of electroencephalographic (EEG) and leg electromyographic (EMG) signals during unconstrained walking. Independent component analysis will be conducted for signal analysis. The connectivity among different brain regions will also be investigated. The PD patients received deep brain stimulation will be recruited for the study. The local field potentials recorded from sub-thalamic nuclei and/or PPN will be recorded concomitantly with EEG and leg EMG signals during unconstrained walking in PD patients to assess the roles of these deep structures in ambulation and their functional connectivity with other brain regions during walking.
Status | Completed |
Enrollment | 50 |
Est. completion date | July 2016 |
Est. primary completion date | July 2015 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Both |
Age group | 20 Years to 85 Years |
Eligibility |
Inclusion Criteria: Patients with PD will be diagnosed according to the Brain Bank criteria. Exclusion Criteria: 1. impairment of cognition that leads unable to fully cooperate with the oral commands during operation. 2. any moderate to severe medical disorders such as poor control of diabetic mellitus, functional III or above congestive heart failure, or cancer with distant metastasis etc. 3. severe mood disorders such as major depression. |
Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Basic Science
Country | Name | City | State |
---|---|---|---|
Taiwan | China Medical University Hospital/Neuro Depart | Taichung |
Lead Sponsor | Collaborator |
---|---|
China Medical University Hospital | National Science Council, Taiwan |
Taiwan,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Recording of electroencephalographic (EEG) and electromyographic (EMG) signals during unconstrained walking. | Variables in gait analysis:1.Gait initiation; 2.Level walking; 3.Turning; 4.Gait termination. | Baseline | No |
Secondary | Unified Parkinson's Disease Rating Scale (UPDRS) | The UPDRS score has three parts, part I (Mentation, Behavior and Mood), Part II (Activities of Daily Living) and Part III (Motor Examination). Each consisting of questions answered on a 0-4 point scale. The minimum total score possible is 0 and the maximum total score possible is 176. Higher scores indicating more severe symptoms. | Baseline | No |
Secondary | The 39-item Parkinson's Disease Questionnaire (PDQ-39) | The PDQ-39 contains 39-items covering 8 discrete dimensions: mobility, activities of daily living, emotional well-being, stigma, social support, cognitions, communication, and bodily discomfort. Each question is scored on a 5-point scale and recoded to 0 to 4 for the analysis. The total score can range from 0 to 132 and with a higher score indicating more severe symptoms. | Baseline | No |
Secondary | The Fall Assessment Test of CMUH | Baseline | No | |
Secondary | Tinetti Performance Oriented Mobility Assessment (POMA) | The Tinetti assessment tool is an easily administered task-oriented test that measures an older adult's gait and balance abilities. The total score can range from 0 to 28 and with a lower score indicating more severe symptoms. | Baseline | No |
Secondary | New freezing of gait questionnaire (NFOG-Q) | The New Freezing of Gait Questionnaire (NFOG-Q) is a clinician-administered tool that aims to assess both the clinical aspects of FOG as well as its subsequent impairments on quality of life. | Baseline | No |
Secondary | Mini-Mental State Examination (MMSE) | MMSE consists of five sections (orientation, registration, attention-calculation, recall, and language) and results in a total possible score of 30, with higher scores indicating better function. | Baseline | No |
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