Parkinson's Disease Clinical Trial
Official title:
[18F]Flubatine: a Novel Biomarker of Cholinergic a4ß2 Nicotinic Receptors and Cognition in Parkinson's Disease
Mild cognitive impairment and dementia are frequent non-motor complications of moderate to advanced Parkinson's disease. Brain positron emission tomography (PET) study findings confirm post-mortem evidence that cholinergic loss is related to cognitive impairment in Parkinson's disease. However, current cholinergic augmentation therapy is not always effective and it should only target those Parkinson's disease patients who have evidence of cholinergic system impairment. The objective of this study is to study the association of a particular subtype of cholinergic receptors, so-called nicotinic acetylcholine receptors, with cognition in Parkinson's disease using a novel PET marker of cholinergic system integrity.
Parkinson's disease patients will undergo nicotinic acetylcholine receptor PET imaging with
the radioligand [18F]flubatine and MRI on one day and extensive neuropsychological testing
on another day. The degree of nicotinic receptor expression obtained with PET imaging will
be correlated with the neuropsychology test results.
Positive [18F]flubatine PET findings in this study would establish nicotinic receptors as an
important contributor to cognitive dysfunction in Parkinson's disease and could kindle
pharmaceutical interest in pursuing these agents for Parkinson's disease applications.
We expect that lower nicotinic receptor expression is associated with impaired cognitive
functioning in Parkinson's disease. In a personalized medicine approach the PET radioligand
[18F]flubatine could serve as an important marker to identify those patients who are
expected to benefit most from nicotinic receptor drug treatment.
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