Effects of Physical Activity on the Brain in Parkinson's Disease (PD)

Parkinson's Disease Clinical Trial

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01741584
• Other study ID #: PA_memory_01
• Status: Completed
• Phase: N/A
• First received: December 3, 2012
• Last updated: March 15, 2016
• Start date: December 2010

Study information

• Verified date: March 2016
• Source: Charite University, Berlin, Germany
• Contact: n/a
• Is FDA regulated: No
• Health authority: Germany: Ethics Commission
• Study type: Interventional

Clinical Trial Summary

The aim of the study is to investigate whether exercise improves cognitive and motor functions in Parkinson's disease. To test this hypothesis, the researchers study general brain functions in subjects with PD during a 6-months exercise program.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 20
• Est. primary completion date: September 2014
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 35 Years to 80 Years

Eligibility

Inclusion Criteria:

• UPDRS <15

• L-DOPA responsive

• <5 yrs since diagnosis

Exclusion Criteria:

• severe other diseases

• MMSE < 26

• treatment with psychiatric medication

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator, Outcomes Assessor), Primary Purpose: Prevention

Related Conditions & MeSH terms

• Parkinson Disease
• Parkinson's Disease

Intervention

Behavioral:
• stationary bike exercise

• aerobic

Locations

Country	Name	City	State
Germany	Department of Neurology, Charité Universitätsmedizin Berlin	Berlin

Sponsors (1)

Lead Sponsor	Collaborator
Charite University, Berlin, Germany

Country where clinical trial is conducted

Germany, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	UPDRS motor score		Prior to intervention and after 6 months of intervention	No
Secondary	Functional/Structural brain changes		Prior to intervention and after 6 months of intervention	No
Secondary	Plasma biomarkers		Prior to intervention and after 6 months of intervention	No
Secondary	Cognitive Function based on neuropsychological test-performance		Prior to intervention and after 6 months of intervention	No