Parkinson´s Disease Clinical Trial
Official title:
Evaluation for the Efficacy,Tolerability,and Safety of Rasagiline in Levodopa-treated PD Patients With Motor Fluctuations: A Multicenter, Double Blind, Randomized, Placebo-Controlled Group Study (China)
The objective of this study is to evaluate the efficacy, tolerability, and safety of rasagiline compared to placebo in PD patients with motor fluctuations on levodopa therapy.
Levodopa has been the mainstay therapy for PD for decades, and it is considered to be one of
the most effective medications for relief of the symptoms of PD. However, within few months
to few years the majority of levodopa-treated patients notice a decline in the duration of
benefit of each dose and develop motor-complications. A major problem is the appearance of
fluctuations in mobility, cycles of ON and OFF periods. The administration of rasagiline, a
MAO-B inhibitor, can slow the elimination of the endogenous dopamine supplies or the
dopamine produced from the exogenous levodopa therapy and may therefore improve ON-OFF
fluctuations.
The objective of this study is to evaluate the efficacy, tolerability, and safety of
rasagiline compared to placebo in PD patients with motor fluctuations on levodopa therapy.
;
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Treatment
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT03866603 -
Rostock International Parkinson's Disease Study (ROPAD)
|
||
| Completed |
NCT00902941 -
Olfaction in Patients With Parkinson's Disease Following Treatment With Rasagiline
|
Phase 4 | |
| Completed |
NCT03103919 -
Study to Evaluate the Impact of Using Wearable Devices in Addition to Standard Clinical Practice on Parkinson´s Subject Symptoms Management
|
Phase 4 | |
| Recruiting |
NCT01650610 -
Gait Training With Executive Functions Tasks in Subjects With Parkinson´s Disease: A Study Protocol
|
N/A | |
| Recruiting |
NCT01650623 -
Gait Training With Executive Functions Tasks in Subjects With Parkinson´s Disease: A Randomised Controlled Trial
|
N/A | |
| Recruiting |
NCT02578849 -
Common Noradrenergic Mechanisms in Parkinson´s Disease and L-DOPA Induced Dyskinesia
|
N/A | |
| Completed |
NCT01003535 -
Quantification of Cerebral Cholinergic Function in Parkinson´s Disease by Means of Nuclear Medicine Methods
|
Phase 1 | |
| Completed |
NCT01038310 -
Prognostic Value of FP-CIT-SPECT in Parkinson´s Disease
|
||
| Terminated |
NCT00562198 -
PET-Study: Effects of Single Doses of Stalevo and Levodopa/Carbidopa on Striatal 11C-Raclopride Binding
|
Phase 2 | |
| Completed |
NCT01580787 -
Functional Improvement in Patients With Parkinson's Disease After Training in Real or Virtual Environment
|
N/A | |
| Completed |
NCT00964652 -
Treadmill Training With Additional Body Load: Effects on Gait of Subjects With Parkinson´s Disease
|
N/A | |
| Completed |
NCT01960985 -
Balance Training in Parkinson's Disease Using Cues
|
Phase 3 | |
| Completed |
NCT01391741 -
The Effect of High-Volume Walking With Visual Cues (VC) in Parkinson´s Disease (PD)
|
Phase 3 |