Parkinson´s Disease Clinical Trial
Official title:
Evaluation for the Efficacy,Tolerability,and Safety of Rasagiline in Levodopa-treated PD Patients With Motor Fluctuations: A Multicenter, Double Blind, Randomized, Placebo-Controlled Group Study (China)
The objective of this study is to evaluate the efficacy, tolerability, and safety of rasagiline compared to placebo in PD patients with motor fluctuations on levodopa therapy.
Levodopa has been the mainstay therapy for PD for decades, and it is considered to be one of
the most effective medications for relief of the symptoms of PD. However, within few months
to few years the majority of levodopa-treated patients notice a decline in the duration of
benefit of each dose and develop motor-complications. A major problem is the appearance of
fluctuations in mobility, cycles of ON and OFF periods. The administration of rasagiline, a
MAO-B inhibitor, can slow the elimination of the endogenous dopamine supplies or the
dopamine produced from the exogenous levodopa therapy and may therefore improve ON-OFF
fluctuations.
The objective of this study is to evaluate the efficacy, tolerability, and safety of
rasagiline compared to placebo in PD patients with motor fluctuations on levodopa therapy.
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Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Treatment
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