Parkinson's Disease Clinical Trial
Official title:
A Longitudinal 5 Years Follow up Study in Parkinson's Disease (PD) Patients Carriers of the LRRK2 Gene G2019S Mutation
This is a longitudinal study in patients with Parkinson's Disease (PD) carriers of a genetic mutation - substitution of gly with ser in position 2019 (G2019S) in the leucine-rich repeat kinase 2 (LRRK2) gene. The purpose of this study is to explore the association between genetic mutations in the known genes and their influence on disease manifestation over few years of follow up
| Status | Not yet recruiting |
| Enrollment | 200 |
| Est. completion date | |
| Est. primary completion date | June 2015 |
| Accepts healthy volunteers | No |
| Gender | Both |
| Age group | 30 Years and older |
| Eligibility |
Inclusion Criteria: - parkinson'd disease patients that already participated in a pasr cross sectional study Exclusion Criteria: - subjects with cognitive decline by the parameters defined in Diagnostic and Statistical Manual of Mental Disorders (DSM)- IV - subjects with psychiatric disorder - subjects unable to sign a consent form |
Observational Model: Cohort
| Country | Name | City | State |
|---|---|---|---|
| Israel | Tel Aviv Sourasky Medical Center | Tel Aviv |
| Lead Sponsor | Collaborator |
|---|---|
| Tel-Aviv Sourasky Medical Center |
Israel,
| Type | Measure | Description | Time frame | Safety issue |
|---|---|---|---|---|
| Primary | change from baseline in updrs motor and total scores | the participants will be followed for 5 years. the measurements will be taken evry 18 month. | No |
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