Parkinson's Disease Clinical Trial
Official title:
Intestinal and Nasal Microbiota of Patients With Idiopathic Parkinson's Disease
The cause of Parkinson's disease (PD) is unknown and a reliable biomarker to identify PD
patients as early as possible is urgently needed. Nerve cells near the nose and in the gut
become first affected in PD and patients frequently suffer from loss of smell and
constipation. The nose and gut harbor very high amounts of bacteria that influence our body
functions in many ways, even in the brain. The investigators are examining a possible role
of bacteria of the nose and gut in the pathogenesis of PD. This may lead to a better
understanding of what PD causes and may open new possibilities for diagnosis and treatment.
The investigators will recruit 100 PD patients and 100 control subjects. The investigators
will characterize all subjects carefully with respect to clinical symptoms. The
investigators will collect bacterial samples from the nose, mouth and stool of these
subjects. Using modern genomic techniques the investigators will read out the genetic code
of all bacteria contained in these samples and will be able to identify which species of
bacteria are present in the samples. Using complex cluster computing the investigators will
compare the pattern of bacterial species between PD patients and controls and look for
specific abnormalities in PD patients.
If the investigators can detect specific differences of bacterial communities between PD
patients and controls this may point to a role of bacteria as a cause of PD. Since there are
many ways to influence bacterial communities pharmacologically (antibiotics, probiotics) it
will be possible to investigate whether these therapies could alleviate or even reverse PD
symptoms. Furthermore, the investigators would be able to use these differences as a
biomarker which would enable us to develop a quick screening test for bacterial samples that
may reveal whether a person has PD or not.
By doing this study the investigators will learn whether bacteria play a role in the
development of PD and whether the investigators can use them as a biomarker or therapeutic
target. So hopefully the investigators will be able in the future to better understand what
causes PD, how the investigators can diagnose it as early as possible and how to cure
patients from PD.
n/a
Observational Model: Case Control, Time Perspective: Cross-Sectional
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT02915848 -
Long-term Stability of LFP Recorded From the STN and the Effects of DBS
|
||
| Recruiting |
NCT03648905 -
Clinical Laboratory Evaluation of Chronic Autonomic Failure
|
||
| Terminated |
NCT02688465 -
Effect of an Apomorphine Pump on the Quality of Sleep in Parkinson's Disease Patients (POMPRENELLE).
|
Phase 4 | |
| Completed |
NCT05040048 -
Taxonomy of Neurodegenerative Diseases : Observational Study in Alzheimer's Disease and Parkinson's Disease
|
||
| Active, not recruiting |
NCT04006210 -
Efficacy, Safety and Tolerability Study of ND0612 vs. Oral Immediate Release Levodopa/Carbidopa (IR-LD/CD) in Subjects With Parkinson's Disease Experiencing Motor Fluctuations
|
Phase 3 | |
| Completed |
NCT02562768 -
A Study of LY3154207 in Healthy Participants and Participants With Parkinson's Disease
|
Phase 1 | |
| Completed |
NCT00105508 -
Sarizotan HC1 in Patients With Parkinson's Disease Suffering From Treatment-associated Dyskinesia
|
Phase 3 | |
| Completed |
NCT00105521 -
Sarizotan in Participants With Parkinson's Disease Suffering From Treatment Associated Dyskinesia
|
Phase 3 | |
| Recruiting |
NCT06002581 -
Repetitive Transcranial Magnetic Stimulation(rTMS) Regulating Slow-wave to Delay the Progression of Parkinson's Disease
|
N/A | |
| Completed |
NCT02236260 -
Evaluation of the Benefit Provided by Acupuncture During a Surgery of Deep Brain Stimulation
|
N/A | |
| Completed |
NCT00529724 -
Body Weight Gain, Parkinson, Subthalamic Stimulation
|
Phase 2 | |
| Active, not recruiting |
NCT05699460 -
Pre-Gene Therapy Study in Parkinson's Disease and Multiple System Atrophy
|
||
| Completed |
NCT03703570 -
A Study of KW-6356 in Patients With Parkinson's Disease on Treatment With Levodopa-containing Preparations
|
Phase 2 | |
| Completed |
NCT03462680 -
GPR109A and Parkinson's Disease: Role of Niacin in Outcome Measures
|
N/A | |
| Completed |
NCT02837172 -
Diagnosis of PD and PD Progression Using DWI
|
||
| Not yet recruiting |
NCT04046276 -
Intensity of Aerobic Training and Neuroprotection in Parkinson's Disease
|
N/A | |
| Recruiting |
NCT02952391 -
Assessing Cholinergic Innervation in Parkinson's Disease Using the PET Imaging Marker [18F]Fluoroethoxybenzovesamicol
|
N/A | |
| Active, not recruiting |
NCT02937324 -
The CloudUPDRS Smartphone Software in Parkinson's Study.
|
N/A | |
| Completed |
NCT02927691 -
Novel Management of Airway Protection in Parkinson's Disease: A Clinical Trial
|
Phase 2 | |
| Terminated |
NCT02924194 -
Deep Brain Stimulation of the nbM to Treat Mild Cognitive Impairment in Parkinson's Disease
|
N/A |