Parkinson's Disease Clinical Trial
Official title:
Ketogenic Diets for Symptoms of Parkinson's Disease
Parkinson's disease is a progressive condition that harms nerve cells of the brain
(neurodegeneration). Current treatments for Parkinson's disease (including levodopa and deep
brain stimulation) improve certain symptoms but are not thought to improve the underlying
neurodegenerative disease process (they are not a "cure"). The cause of Parkinson's disease
is unknown. However, some evidence suggests that tiny structures in the investigators cells
called "mitochondria" might be involved. Mitochondria are the powerhouses that produce fuel
for the investigators cells. Failure of these 'powerhouses' to supply the energy needs of
certain nerve cells might lead to Parkinson's disease. Preliminary evidence suggests that a
food called 'ketones' might be able to enhance the function of mitochondria and improve
Parkinson's disease symptoms and possibly even the neurodegenerative process. In this study,
the investigators would like to investigate this possibility by giving patients with
Parkinson's disease dietary supplements of 'ketone esters' in a drink. The investigators
will then assess if this improves symptoms of Parkinson's disease.
The study design is a prospective, double blinded, randomised, controlled trial.
n/a
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Outcomes Assessor), Primary Purpose: Treatment
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