Web-based Genetic Research on Parkinson's Disease

Parkinson's Disease Clinical Trial

Official title:

Ongoing, Web-Based Genome-Wide Association Studies for Targeted Disease Initiatives

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01351467
• Other study ID #: 23andMe_PD001
• Status: Completed
• Start date: April 2009
• Est. completion date: June 23, 2021

Study information

• Verified date: November 2022
• Source: 23andMe, Inc.
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

The purpose of this study is to examine how genes and environment affect risk for Parkinson's disease.

Description:

23andMe has created a web-based Parkinson's research initiative to understand the genetic associations found between Parkinson's patients' DNA and their disease. To learn more, visit: https://www.23andme.com/pd/. You can participate in this research initiative without leaving home. If you are eligible to participate, we will send you an in-home 23andMe DNA kit at no cost. We will ask you short online surveys (15-20) about your Parkinson's journey, symptoms, and response to treatment. Enrollment is on-going and open to individuals who have been diagnosed with Parkinson's disease and are residents of the U.S. Participants receive access to ancestry information and uninterpreted genetic data. Participants will also receive regular updates on our research efforts and findings.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 13576
• Est. completion date: June 23, 2021
• Est. primary completion date: June 23, 2021
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• diagnosis of Parkinson's disease by a physician

Exclusion Criteria:

• diagnoses other than Parkinson's, including:

• progressive supranuclear palsy (PSP)

• multiple system atrophy (MSA)

• Shy-Drager syndrome

• spinal cerebella ataxia (SCA)

• atypical parkinsonism

• parkinsonism due to medications, drug-induced parkinsonism

• vascular parkinsonism

• frontotemporal dementia with parkinsonism

Related Conditions & MeSH terms

• Parkinson Disease
• Parkinson's Disease

Locations

Country	Name	City	State
United States	Www.23Andme.Com/Pd	Mountain View	California

Sponsors (3)

Lead Sponsor	Collaborator
23andMe, Inc.	Michael J. Fox Foundation for Parkinson's Research, The Parkinson's Institute

Country where clinical trial is conducted

United States, 

References & Publications (4)

Do CB, Tung JY, Dorfman E, Kiefer AK, Drabant EM, Francke U, Mountain JL, Goldman SM, Tanner CM, Langston JW, Wojcicki A, Eriksson N. Web-based genome-wide association study identifies two novel loci and a substantial genetic component for Parkinson's dis — View Citation

Lill CM, Roehr JT, McQueen MB, Kavvoura FK, Bagade S, Schjeide BM, Schjeide LM, Meissner E, Zauft U, Allen NC, Liu T, Schilling M, Anderson KJ, Beecham G, Berg D, Biernacka JM, Brice A, DeStefano AL, Do CB, Eriksson N, Factor SA, Farrer MJ, Foroud T, Gass — View Citation

Nalls MA, Pankratz N, Lill CM, Do CB, Hernandez DG, Saad M, DeStefano AL, Kara E, Bras J, Sharma M, Schulte C, Keller MF, Arepalli S, Letson C, Edsall C, Stefansson H, Liu X, Pliner H, Lee JH, Cheng R; International Parkinson's Disease Genomics Consortium — View Citation

Pichler I, Del Greco M F, Gögele M, Lill CM, Bertram L, Do CB, Eriksson N, Foroud T, Myers RH; PD GWAS Consortium, Nalls M, Keller MF; International Parkinson's Disease Genomics Consortium; Wellcome Trust Case Control Consortium 2, Benyamin B, Whitfield J — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Saliva DNA test and online surveys with questions about Parkinson's disease experience, symptoms and response to treatment	We want to learn how genes and environment could play role in Parkinson's disease risk and progression	Intermittent surveys every 6 months for up to 24 months

External Links

•   Click here for more information about this study: Web-based Genetic Research on Parkinson's Disease