Parkinson's Disease Clinical Trial
Official title:
High Frequency rTMS (Repetitive Transcranial Magnetic Stimulation) Effect Applied on Primary Cortical Motor, on Nociceptive Perception Thresholds in Parkinson's Disease Patients: a Physiopathology Study
Pain is a frequent symptom in Parkinson's disease. Previous studies have shown that pain
perception was altered in Parkinson's disease patients and could be related to nociceptive
cortical area hyperactivation. Repetitive Transcranial Magnetic Stimulation is an
electrophysiological tool which can modify cortical excitability. Its efficacy was
demonstrated in neuropathic pain. This is a randomized, double blind cross-over study. In
this study, subjective pain threshold (using thermal stimulation (Thermotest)).will be
evaluated in 3 groups of subjects: healthy volunteers, painful Parkinson's patients and pain
free Parkinson's disease patients. Each group will receive a high frequency Repetitive
Transcranial Magnetic Stimulation and placebo stimulation in different order with a gap of
one week.
The investigators supposed that a 20 Hz Repetitive Transcranial Magnetic Stimulation session
with an infraliminary intensity on the primary cortical motor, modulating nociceptive
cortical areas activity, could modify the nociceptive threshold perception in Parkinson's
patients.
n/a
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Basic Science
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