7T MRS in Parkinson's Disease

Status Completed

Clinical Trial Summary

This study is looking for healthy controls and patients with Parkinson's (PD) to perform an MR scan.

1. The neurochemical profile of the SN of patients with PD as measured by high field MRS will differ from that of healthy controls, in that glutathione will be lower due to oxidative stress, lactate will be higher due to mitochondrial dysfunction, the gliosis markers myo-inositol and glutamine will be higher due to inflammation (glial activation) and N-acetylaspartate and glutamate will be lower due to neuronal loss/damage.

2. There will be a relationship between neurochemical changes and disease severity.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT01237210
Study type	Observational
Source	University of Minnesota
Contact
Status	Completed
Phase
Start date	February 2010
Completion date	February 2019

View Details

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