Parkinson's Disease Clinical Trial
Official title:
Effect of Robot-assisted Gait Training on Freezing of Gait in Parkinson's Disease
Freezing of gait (FOG) is a common yet poorly understood motor symptom in persons with
Parkinson's disease (PD). Previous studies have shown that bilateral uncoordinated gait and
gait asymmetry are related to FOG, and that intensive treadmill training in PD patients can
improve gait. However, no group has yet studied the effect of robot-assisted gait training
(RAGT) on FOG. The primary aim of this study is to collect pilot data on the effect of
robot-assisted gait training in reducing episodes of freezing in PD.
Subjects with Parkinson's disease that experience freezing of gait will be recruited and
enrolled following informed consent and screening for eligibility. Each of the 10 training
session will last approximately one hour. Neurological evaluations, testing of gait
parameters, and quality of life assessments will be conducted. Participants will also be
asked to return for 1- and 3-month post-intervention assessments to see if the training has
any lasting effects. Approximately 10-20 subjects will be enrolled, and the study will last
up to 6 months.
Robot-assisted gait training will be conducted with the Lokomat (a treadmill with
supplemental robot-assistance for moving the hip and knee). We will monitor changes in
freezing by conducting various assessments.
There are approximately 1 million Americans with PD in the US. PD is a significant cause for
reduced functional ability and quality of life, progressive disability. Patients with PD with
FOG have indicated that this is one of their most disturbing symptoms, as there are no
effective treatments. Therefore it is important that additional and alternative interventions
for FOG be tested and developed.
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