Parkinson's Disease Clinical Trial
Official title:
Dexmedetomidine Effects on Microelectrode Recording in Deep Brain Stimulation
To test the hypothesis that sedation induced by Dexmedetomidine at levels appropriate for awake, DBS surgery has no significant effect on electrophysiological parameters of DBS micro-electrode recordings
Deep brain stimulator (DBS) implants are used in the treatment of medically refractory
movement disorders such as Parkinson's disease, essential tremor and dystonia. Because of
the uniqueness of each individual brain, the surgery to implant a DBS electrode requires
detailed anatomic and physiological information for each patient. The anatomic data is
obtained before surgery via a Magnetic Resonance Imaging (MRI) scan of the patient's brain.
Physiological data is obtained during the operation via micro-electrode recording of the
patient's brain and neurological examination of the patient. Therefore, DBS surgery can be
uncomfortable to patients, as it can be very time consuming and requires the patient to be
awake and attentive.
The specific aims of this project are:
1. To test the hypothesis that sedation induced by Dexmedetomidine at levels appropriate
for awake, DBS surgery has no significant effect on electrophysiological parameters of
DBS micro-electrode recordings.
2. To test the hypothesis that sedation induced by Dexmedetomidine at levels appropriate
for awake, DBS surgery have no significant effects on neurological findings and/or
patient cooperation during neurological examination.
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment
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