Twins and the Risk of Parkinson's Disease: A Clinical and Imaging Study

Parkinson's Disease Clinical Trial

Official title:

Twins and the Risk of PD: A Clinical and Imaging Study

Clinical Trial Details — Status: Active, not recruiting

Administrative data

• NCT number: NCT00282802
• Other study ID #: R01NS040467
• Secondary ID: R01NS040467-01
• Status: Active, not recruiting
• Phase: N/A
• First received: January 26, 2006
• Last updated: July 1, 2009
• Start date: April 2001
• Est. completion date: July 2010

Study information

• Verified date: July 2009
• Source: The Parkinson's Institute
• Contact: n/a
• Is FDA regulated: No
• Health authority: United States: Federal Government
• Study type: Observational

Clinical Trial Summary

The purpose of this study is to examine the role of genetic and environmental factors in the cause of Parkinson's disease.

Description:

Parkinson's disease (PD) is a growing health problem in the elderly, and genetic factors may provide substantial clues toward eventual treatment and/or prevention of the disorder. The National Academy of Sciences/National Resource Council (NAS/NRC) World War II (WWII) Veteran Twins Cohort Registry is one of the few population-based groups of elderly twins. Previous studies in this group indicated that genetic factors were involved only in early-onset PD, however there was no follow-up to these studies.

The purpose of the "Twins and the Risk of PD" study is to follow-up previous studies and confirm the initial findings. In this study, investigators will use the NAS/NRC WWII Veteran Twin Cohort Registry to compare the concordance rates for PD in monozygotic and dizygotic twins—at least one of whom has PD.

The overall goal of this research is determine the contributions of genetic and environmental factors in the cause of PD.

The study will involve traditional clinical research methods, such as a clinical examination, as well as innovative imaging techniques, such as single photon emission computed tomography (SPECT). SPECT—a nuclear imaging test involving blood flow to tissue—is used to evaluate certain brain functions.

Findings from this study may help to set research priorities in PD, and to develop tools for early detection of the disorder.

Recruitment information / eligibility

• Status: Active, not recruiting
• Enrollment: 250
• Est. completion date: July 2010
• Accepts healthy volunteers: No
• Gender: Male
• Age group: 77 Years to 88 Years

Eligibility

Inclusion:

• Participants will be recruited from a closed cohort—the National Academy of Sciences/National Resource Council (NAS/NRC) World War II Veteran Twins Cohort

Study Design

Observational Model: Cohort, Time Perspective: Prospective

Related Conditions & MeSH terms

• Parkinson Disease
• Parkinson's Disease

Locations

Country	Name	City	State
United States	The Parkinson's Institute, 675 Almanor Avene	Sunnyvale	California

Sponsors (2)

Lead Sponsor	Collaborator
The Parkinson's Institute	National Institute of Neurological Disorders and Stroke (NINDS)

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Onset of Parkinson's disease		duration of the project	No
Secondary	Age of Parkinson's disease onset		duration of the project	No