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Clinical Trial Summary

A Phase 1, randomized, double-blind, placebo-controlled study of BMS-984923 administered orally twice daily (BID) for 28 days in participants with Parkinson's disease.


Clinical Trial Description

This double-blind placebo-controlled study will evaluate 28 days of twice daily dosing of BMS-984923 at two dose levels in comparison to placebo in participants with early Parkinson's disease. This research study will assess the safety and tolerability of multiple doses of BMS-984923 for the treatment of early Parkinson's disease and investigate Dopamine transporter levels in the brain measured with single photon emission computed tomography as an early marker of therapeutic response to a treatment that targets synapse restoration. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT06309147
Study type Interventional
Source Allyx Therapeutics
Contact Alexis Schuettke
Phone 919-668-2842
Email Alexis.schuettke@duke.edu
Status Recruiting
Phase Phase 1
Start date March 15, 2024
Completion date July 15, 2025

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