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Clinical Trial Summary

The overall goal of this protocol is to investigate [18F]DPA-714 binding in prodromal and early manifest Parkinson's Disease (PD) and to determine the baseline and change from baseline in [18F]DPA-714 binding in PD participants during a 24-month interval. Primary Objectives - To compare [18F]DPA-714 binding in prodromal and manifest PD and healthy volunteers. - To determine the longitudinal change in [18F]DPA-714 during a 24-month interval for prodromal and early initially untreated PD participants. Secondary Objectives - To evaluate the correlation between baseline [18F]DPA-714 and PPMI clinical and biomarker outcomes. - To evaluate the correlation between the longitudinal change of [18F]DPA-714 and PPMI clinical and biomarker outcomes - To acquire safety data following injection of [18F]DPA-714


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT06289582
Study type Interventional
Source University of Alabama at Birmingham
Contact Evan Hudson
Phone 205-934-6499
Email evanhusdon@uabmc.edu
Status Not yet recruiting
Phase Early Phase 1
Start date June 2024
Completion date June 2027

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