Stimulus-Evoked Directional Field Potentials to Guide Subthalamic and Pallidal DBS for PD

Parkinson Disease Clinical Trial

Official title: Stimulus-Evoked Directional Field Potentials to Guide Subthalamic and Pallidal DBS for PD

Status Recruiting

Clinical Trial Summary

The purpose of the study is to determine whether new deep brain stimulation (DBS) device technologies can generate and record brain rhythms to reveal the best location for clinical stimulation.

Clinical Trial Description

The investigator's goal is to better understand how deep brain stimulation (DBS) modifies local neuronal activity and to pioneer device technologies that can record local DBS-evoked potentials (DLEPs) to guide therapy. Together, Neuromodulation eXperiment Testbed system (NEXT) with a novel 16-contact directional lead (Argyle) are uniquely suited for these purposes. The investigator's vision is for NEXT to guide both electrode targeting during surgery and programming in clinic, eventually as an integrated component of the implanted pulse generator. The results will inform directional DBS for PD and serve as a model for translation to other diseases where knowledge on DBS circuit interactions is at an even earlier stage. ;

Related Conditions & MeSH terms

• Parkinson Disease

• NCT number: NCT06169852
• Study type: Interventional
• Source: University of Alabama at Birmingham
• Contact: Harrison Walker, MD
• Phone: 205-934-0683
• Email: hcwalker@uabmc.edu
• Status: Recruiting
• Phase: N/A
• Start date: January 12, 2024
• Completion date: January 1, 2029