Parkinson Disease Clinical Trial
— PD FrontlineOfficial title:
PD Frontline, Part of RAPSODI GD (Remote Assessment of Parkinsonism Supporting Ongoing Development of Interventions in Gaucher's Disease) to Build an Online Trial-ready Cohort of GBA Genotyped People With Parkinson's
NCT number | NCT06151002 |
Other study ID # | 173275 |
Secondary ID | |
Status | Recruiting |
Phase | |
First received | |
Last updated | |
Start date | February 15, 2020 |
Est. completion date | August 20, 2040 |
PD Frontline (part of RAPSODI GD) is an online study observational study with the goal of bringing People with Parkinson's to the frontline of research by getting them trial ready. To do this, participants are offered genetic sequencing for the GBA and LRRK2 gene with an at-home saliva collection kit.
Status | Recruiting |
Enrollment | 4800 |
Est. completion date | August 20, 2040 |
Est. primary completion date | February 14, 2025 |
Accepts healthy volunteers | |
Gender | All |
Age group | 18 Years to 90 Years |
Eligibility | Inclusion Criteria: - Formal diagnosis of Parkinson Disease Exclusion Criteria: - Confirmation that the individual carries a GBA variant (GBA positive). These individuals will be referred to sister-study, RAPSODI. - History of Parkinsonism (progressive supranuclear palsy, multiple system atrophy, traumatic, manganese toxicity, postencephalitic, vascular PD; drug induced PD; corticobasal degeneration) - Individuals with another neurological disorder including: dementia, movement disorders, and motor neurone disease. - Individuals on drugs known to be associated with parkinsonism, including neuroleptic agents (Amisulpride, Chlorpromazine Hydrochloride, Flupenthixol, Fluphenazine Hydrochloride, Haloperidol, Methotrimeprazine, Levomepromazine, Olanzapine, Oxypertine, Pericyazine, Perphenazine, Pimozide, Pipotiazine, Prochlorperazine, Promazine Hydrochloride, Reserpine, Risperidone, Sulpiride, Thioridazine, Trifluoperazine, Zuclopenthixol acetate, Zotepine), plus Bupropion, , Lithium, Methyldopa, Metoclopramide and Sodium Valproate). |
Country | Name | City | State |
---|---|---|---|
United Kingdom | University College London (UCL) | London |
Lead Sponsor | Collaborator |
---|---|
University College London Hospitals | Cure Parkinson's |
United Kingdom,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Genotype of participants | The primary outcome of the study is to genotype the GBA1 gene, obtained with Oxford Nanopore long read sequencing. | 20 years |
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