Gait Control in Parkinson Disease

Parkinson Disease Clinical Trial

— GAIT-PD  

Official title:

Flexible Control of Gait in Parkinson Disease: Effect of Task Instruction on the Exploitation of Redundancy in Speed Control.

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT05908279
• Other study ID #: GAIT-PD
• Status: Recruiting
• Start date: May 1, 2023
• Est. completion date: October 31, 2027

Study information

• Verified date: June 2023
• Source: Université Catholique de Louvain
• Contact: André Mouraux, PhD
• Phone: +32 2 764 54 47
• Email: andre.mouraux[@]uclouvain.be
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Previous work has shown that a statistical property of gait characterised by long-range autocorrelation functions is altered in Parkinson disease (PD). On the other hand it has been suggested that the same property is linked to the ability in healthy humans to co-regulate the amplitude and cadence of strides towards maintaining a constant speed. Here the investigators want to better understand why it is altered in PD by measuring the transitions between gait instructed by a metronome, and gait without metronome. The experimental conditions will allow the comparisons between these transitions across PD and healthy groups of volunteers, and assess differences based on statistical and computational modelling. The link with potential freezing episodes will also be studied to assess whether the statistical determinants of gait control in this population can be used as a proxy or predictor of the occurence of freezing episodes.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 100
• Est. completion date: October 31, 2027
• Est. primary completion date: October 31, 2027
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 99 Years

Eligibility

Inclusion Criteria:

• Patients and volunteers able to walk for 20mins and without other neurological disorders.

Exclusion Criteria:

• Patients or volunteers unable to walk for 20mins and with other neurological disorders.

Related Conditions & MeSH terms

• Parkinson Disease

Intervention

Other:
• Walking test
Walk with and without a metronome
• Disease assessement
Disease stage assessed by a doctor

Locations

Country	Name	City	State
Belgium	Université catholique de Louvain	Louvain-la-Neuve

Sponsors (1)

Lead Sponsor	Collaborator
Université Catholique de Louvain

Country where clinical trial is conducted

Belgium, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Stride cadence	Time between two consecutive heel strikes. Units are seconds.	Measured during the entire experiment (an average of 4.5 years)
Primary	Stride amplitude	Distance between two consecutive heel strikes. Units are meters.	Measured during the entire experiment (an average of 4.5 years)