Flexible Reaching Control in Parkinson Disease

Parkinson Disease Clinical Trial

— REACH-PD  

Official title:

Behavioural Study of Reaching Control in Healthy Volunteers and Volunteers With Parkinson Disease in Dynamical Context

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT05908266
• Other study ID #: REACH-PD
• Status: Recruiting
• Start date: May 1, 2023
• Est. completion date: October 31, 2027

Study information

• Verified date: June 2023
• Source: Université Catholique de Louvain
• Contact: André Mouraux, PhD
• Phone: +32 2 764 54 47
• Email: andre.mouraux[@]uclouvain.be
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Current research and theories have highlighted that the parameters linked to movement planning, e.g. the decision to select a movement goal, and adaptation, e.g. the ability to update control dependent on a novel dynamical context, are update quickly and within an ongoing movement in the general population. In parallel, it has been suggested that the evaluation of movement costs is a function of the basal ganglia, and it is impaired in Parkinson disease (PD). Here the investigators want to test whether these mechanisms also alter the ability of patients to update control during an ongoing action. A positive result would confirm that movement-related costs and dynamical representations depend on the integrity of the basal ganglia, in contrast a negative result would indicate that the deficit in PD is more specifically related to movement initiation, which would invite one to reconsider the cause of bradykinesia in this population.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 100
• Est. completion date: October 31, 2027
• Est. primary completion date: October 31, 2027
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 99 Years

Eligibility

Inclusion Criteria:

• Ability to perform the task (assessed during the experiment)

Exclusion Criteria:

• Inability to perform the task (motor) or to understand the task requirements (cognitive)

Related Conditions & MeSH terms

• Parkinson Disease

Intervention

Other:
• Reaching movements
Participants will be instructed to perform reaching movements by moving the handle of a robotic arm mounted with a virtual reality display.
• Disease Assessment
Disease stage assessed by trained professionals

Locations

Country	Name	City	State
Belgium	Université catholique de Louvain	Louvain-la-Neuve

Sponsors (1)

Lead Sponsor	Collaborator
Université Catholique de Louvain

Country where clinical trial is conducted

Belgium, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Kinematics	Position of the handle as a function of time. Units are millimetres	Measured during the entire experiment (an average of 4.5 years)
Primary	Surface Electromyogram	Surface recordings of muscles activities from the main muscles involved in movement production. Units are volts	Measured during the entire experiment (an average of 4.5 years)
Primary	Applied forces	Forces applied by participants on the robotic handle. Units are Newtons	Measured during the entire experiment (an average of 4.5 years)