Pyridostigmine for the Treatment of Constipation in Parkinson Disease

Status Recruiting

Clinical Trial Summary

Constipation is a common and debilitating non-motor symptom of Parkinson disease (PD) that often precedes the onset of classic motor symptoms by decades. There is no standardized algorithm for managing constipation in this patient population, nor are there dedicated treatments. Studies suggest that constipation can affect quality of life to a significant degree, in many cases just as much as motor symptoms. There is an unmet need for effective treatment options for constipation in this patient population. The goal of this study is to determine the efficacy and safety of pyridostigmine as a treatment for chronic constipation in patients with PD.

Clinical Trial Description

This is a 13-15 week open-label, dose escalation trial of pyridostigmine 60-180mg three times a day (TID) for the treatment of constipation in patients with Parkinson disease. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05603715
Study type	Interventional
Source	University of Vermont Medical Center
Contact	Lisa M Deuel, MD
Phone	(802) 847-4589
Email	Lisa.Deuel@uvmhealth.org
Status	Recruiting
Phase	Phase 2
Start date	August 10, 2022
Completion date	December 2024

View Details

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