Istradefylline for Parkinson Disease With Cognitive Impairment

Status Recruiting

Clinical Trial Summary

The purpose of this research study is to determine whether istradefylline improves cognition in individuals with Parkinson disease with cognitive impairment.

Clinical Trial Description

Istradefylline has been approved by the U. S. Food and Drug Administration (FDA) to reduce "off" episodes in Parkinson disease. The period when levodopa has a positive effect on Parkinson's symptoms is called on-time. Once the medication stops working, a so called "off" episode starts, where symptoms recur. Usual care for treatment of Parkinson disease with cognitive impairment is use of cognition enhancing medications also called cholinesterase inhibitors. In this study, participants will receive usual care, and in addition, they will be asked to take istradefylline daily for 26 weeks. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05333549
Study type	Interventional
Source	Virginia Commonwealth University
Contact	Kara McHaney
Phone	804-828-4788
Email	kara.mchaney@vcuhealth.org
Status	Recruiting
Phase	Phase 2
Start date	July 18, 2022
Completion date	July 2025

View Details

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