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Molecular Imaging of Inflammation in Parkinson's Disease Using LPS and TSPO-PET/MR

Parkinson Disease Clinical Trial

Official title:
Molecular Imaging of LPS-induced Microglial Activation in Parkinson's Disease (PD). A TSPO PET-MR Imaging Study

Clinical Trial Summary

It is not known what causes Parkinson's disease and what makes it worsen over time. Research conducted in the past few years has highlighted the possible role of inflammation on this process but its actual mechanisms are still obscure. In this study, the investigators aim to gain understanding on how inflammation is increased in Parkinson's disease and what are its mechanisms, by performing two Positron Emission Tomography (PET) scans using the tracer [11C]PBR28, that takes pictures of the brain highlighting the areas of inflammation, before and after the administration of a compound called Lipopolysaccharide or LPS, that is known to cause a mild degree of inflammation. The investigators will couple this study with two venous blood draws to measure the levels of circulating molecules of inflammation.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05205291
Study type Observational
Source University of Exeter
Contact Edoardo R. de Natale, MD MSc Ph.D
Phone 07503741242
Email e.de-natale@exeter.ac.uk
Status Recruiting
Phase
Start date February 28, 2022
Completion date September 30, 2024
View Details
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