Understanding Motivation in Parkinson's Patients Through Neurophysiology

Parkinson Disease Clinical Trial

— MPPN  

Official title:

Understanding Motivation in Parkinson's Patients Through Neurophysiology

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT05065151
• Other study ID #: 20-31239
• Status: Recruiting
• Phase: N/A
• Start date: October 30, 2021
• Est. completion date: October 1, 2024

Study information

• Verified date: May 2024
• Source: University of California, San Francisco
• Contact: Sarah Wang, PhD
• Phone: 415-353-7885
• Email: Sarah.Wang[@]ucsf.edu
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The study's aim is to better understand motivation and value-based decision making in Parkinson's patients through neurophysiology using Medtronic's Percept PC DBS device.

Description:

The investigators will ask patients to complete reward-based decision making tasks in clinic and at home in the presence and absence of Percept PC deep brain stimulation and medication. The Percept PC device has the ability to stream data during paradigms and chronically at home. Patients at home will also be fitted with a wearable device which records motion, sleep, heart rate variability, and self-reported metrics. The investigators will use spectral techniques and statistical analysis to identify the relationship between brain signals and motivation.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 20
• Est. completion date: October 1, 2024
• Est. primary completion date: October 1, 2024
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Has Parkinson's Disease

• Has Medtronic Percept PC DBS device implanted in either GPI or STN

Exclusion Criteria:

• Severe cognitive impairments

Related Conditions & MeSH terms

• Deep Brain Stimulation
• Motivation
• Parkinson Disease

Intervention

Other:
• Stimulation on
Stimulation from Percept PC DBS will be on while the patient is playing a decision-making game on a computer-based application.
• Stimulation off
Stimulation from Percept PC DBS will be off while the patient is playing a decision-making game on a computer-based application.

Behavioral:
• Decision Making Task
Patients will be playing a decision making task through a computer-based application.

Locations

Country	Name	City	State
United States	University of California San Francisco	San Francisco	California

Sponsors (3)

Lead Sponsor	Collaborator
University of California, San Francisco	Rune Labs, Yale University

Country where clinical trial is conducted

United States, 

References & Publications (4)

Blain B, Rutledge RB. Momentary subjective well-being depends on learning and not reward. Elife. 2020 Nov 17;9:e57977. doi: 10.7554/eLife.57977. — View Citation

Eldar E, Rutledge RB, Dolan RJ, Niv Y. Mood as Representation of Momentum. Trends Cogn Sci. 2016 Jan;20(1):15-24. doi: 10.1016/j.tics.2015.07.010. Epub 2015 Nov 3. — View Citation

Rutledge RB, Skandali N, Dayan P, Dolan RJ. A computational and neural model of momentary subjective well-being. Proc Natl Acad Sci U S A. 2014 Aug 19;111(33):12252-7. doi: 10.1073/pnas.1407535111. Epub 2014 Aug 4. — View Citation

Rutledge RB, Skandali N, Dayan P, Dolan RJ. Dopaminergic Modulation of Decision Making and Subjective Well-Being. J Neurosci. 2015 Jul 8;35(27):9811-22. doi: 10.1523/JNEUROSCI.0702-15.2015. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Percent of Risky Decisions made with Percept PC DBS stimulation on for Parkinson's Disease Patients	Patients' responses on the tablet will be recorded in-clinic and at home. The investigators will tally their choices from the value-based decision making game (risky versus safe decisions) and report an average of risky responses.	The values will be collected starting from admission in clinic and the at-home paradigm. Data collection and analysis of said values can take up to three years
Primary	Percent of Risky Decisions made with Percept PC DBS stimulation off for Parkinson's Disease Patients	Patients' responses on the tablet will be recorded in-clinic and at home. The investigators will tally their choices from the value-based decision making game (risky versus safe decisions) and report an average of risky responses.	The values will be collected starting from admission in clinic and the at-home paradigm. Data collection and analysis of said values can take up to three years