Clinical Trial Details
— Status: Completed
Administrative data
| NCT number |
NCT04970745 |
| Other study ID # |
M2018222 |
| Secondary ID |
|
| Status |
Completed |
| Phase |
|
| First received |
|
| Last updated |
|
| Start date |
January 1, 2018 |
| Est. completion date |
August 1, 2019 |
Study information
| Verified date |
June 2021 |
| Source |
Peking University Third Hospital |
| Contact |
n/a |
| Is FDA regulated |
No |
| Health authority |
|
| Study type |
Observational
|
Clinical Trial Summary
This is a longitudinal study to evaluate the brainstem of patients at different stages
through VEMP neck, masticatory muscle and eye tests on patients with early and
middle-advanced PD (20 cases each) and healthy controls (40 cases) The function of various
parts is affected. At the same time, combining the patient's neurological function score and
non-motor symptom score to find evidence of early involvement and early intervention.
Description:
[Background] Tremor is an important symptom of extrapyramidal diseases, and it is also an
early symptom of a variety of complex diseases. The classification of tremor has not been
completely unified, mainly including essential tremor, Parkinson's disease tremor, etc., each
form of tremor has Crossover and connection make clinical differential diagnosis difficult.
At the same time, many diseases related to tremor lack pathological, serological and imaging
characteristic changes. Therefore, it is particularly important to find accurate and
objective evaluation indicators for tremor.
By recording a pair of antagonist muscles (active muscles and passive muscles),
electromyography can objectively record the type, degree, amplitude, burst pattern (whether
the burst activity of the antagonistic muscles are synchronized or alternate), and
weight-bearing The effect of drugs on tremor is very valuable for the diagnosis and
differential diagnosis of tremor; especially for patients with Parkinson's disease, it can be
several years or even decades before they develop motor symptoms, that is, tremor, rigidity,
slowness of movement, and postural instability. There are a wide range of non-motor symptoms,
such as smell, mood, sleep, mental behavior and many other aspects. Compared with dyskinesia,
non-motor symptoms are both a precursor to the onset and an indication of disease
progression. Fully understanding and exploring the law of the occurrence and development of
these non-motor symptoms can provide clues for our early diagnosis and provide us with
opportunities for early implementation of neuroprotective treatment.
The early clinical symptoms of Parkinson's disease (Pakinson's disease, PD) are often
atypical, and it is difficult to diagnose it only based on the history and clinical
manifestations. However, when the diagnosis is made when the clinical symptoms are obvious,
the patient's substantia nigra dopamine neurons have been reduced by 60-70%, and the
opportunity for early treatment is lost. A Berg study also showed that treatment when most
neurons in the pre-exercise period have not undergone degeneration can better protect the
nerves and may delay the clinical progress of PD. Therefore, early diagnosis and early
treatment of PD patients are particularly important.
The clinical manifestations of Parkinson's disease include motor symptoms and non-motor
symptoms (NMS), the latter of which is often ignored by clinicians. It includes common
neuropsychiatric symptoms: such as depression, anxiety, apathy, lack of affect, distraction,
and even hallucinations, delusions, delusions, dementia, obsessive-compulsive symptoms, panic
attacks; sleep disorders: periodic limb movement disorders, excessive sleep during the day
and so on. Some of these symptoms can appear before the movement disorder of Parkinson's
disease, some are accompanied by the movement disorder, and some appear in the middle and
late stages of Parkinson's disease, and aggravate with the aggravation of the movement
symptoms. And its NMS is closely related to the severity of the entire disease of PD.
[Objective] To explore the significance of tremor analysis in judging the early diagnosis of
Parkinson's disease.
Discuss the significance of tremor analysis for the prognosis of the disease. To explore the
diagnostic significance of tremor analysis in patients with Parkinson's disease and benign
tremor.
[Design] This is a longitudinal study to evaluate the brainstem of patients at different
stages through VEMP neck, masticatory muscle and eye tests on patients with early and
middle-advanced PD (20 cases each) and healthy controls (40 cases) The function of various
parts is affected. At the same time, combining the patient's neurological function score and
non-motor symptom score to find evidence of early involvement and early intervention.
