Outcome
Type |
Measure |
Description |
Time frame |
Safety issue |
Primary |
Functional MRI activity during a motor task |
Functional MRI activity during isolated/coordinated movements of the upper and lower limbs |
Baseline |
|
Secondary |
Movement Disorder Society Unified Parkinson's Disease Rating Scale |
Only the motor section will be scored. Maximum points: 84 (the higher the score, the more severe the motor symptoms) |
Baseline |
|
Secondary |
Kinesia One |
Instrumented measures of motor dysfunction in Parkinson's disease. Maximum points: 72 (the higher the score, the more severe the motor symptoms) |
Baseline |
|
Secondary |
Timed Up and Go |
Mobility test (instrumented). Measures: duration (s), lean angle during sit/stand (degrees), turning duration (s) and turning angle (degrees) |
Baseline |
|
Secondary |
360-Degree Turn Test |
Instrumented test measuring dynamic balance. Measures: turning angle (degrees), turning duration (s), turning velocity (degrees/s) |
Baseline |
|
Secondary |
Five Times Sit to Stand |
Instrumented test measuring ability to perform transitional movements (i.e., get up from a chair). Measures: Duration (s), duration of the different phases (sitting/standing) (s), lean angle during the two phases (sitting/standing) (degrees) |
Baseline |
|
Secondary |
The Modified Clinical Test of Sensory Interaction and Balance (mCTSIB) |
Instrumented test assessing balance under different test conditions (eyes open/closed on firm/foam surface). Measures of postural sway: sway area (m^2/s^4), jerk (m^2/s^5), mean velocity (m/s), path length (m/s^2) |
Baseline |
|
Secondary |
2-Minute Walking Test |
Instrument test assessing gait under three different conditions: 1) self-selected/normal speed, 2) self-selective/normal speed + cognitive task, 3) fast speed. Measures calculated for each condition/side of body: cadence (steps/min), double support (%GCT), gait cycle duration (s), gait speed (m/s), lateral step variability (cm), toe off angle (degrees), foot strike angle (degrees), turn velocity (degrees/s), upper limb range of motion (degrees), arm swing velocity (degrees/s). |
Baseline. |
|
Secondary |
Purdue Pegboard Test |
Test measuring dexterity by counting the number of pegs placed on the pegboard during a given time. |
Baseline |
|
Secondary |
Grooved Pegboard |
Test measuring dexterity by counting how long it takes to place a given number of pegs on the pegboard. |
Baseline |
|
Secondary |
Montreal Cognitive Assessment Test |
Test measuring global cognitive function. Maximum points: 30 (the higher the score, the better the cognitive function) |
Baseline |
|
Secondary |
Brief Test of Attention |
Test measuring attention. Two sections are used that evaluate attention during reading of lists of letters and numbers. Maximum points across the two sections: 20 (the higher the score, the better the attention) |
Baseline |
|
Secondary |
Beck Depression Inventory II |
Questionnaire measuring depression. Maximum points: 63 (high score indicates depression) |
Baseline |
|
Secondary |
Parkinson's Disease Questionnaire (PDQ-39) |
Questionnaire measure health-related quality of life. Eight dimensions ranging from 0-100 (the higher the score, the worse the quality of life) |
Baseline |
|
Secondary |
Schwab and England Activities of Daily Living Scale |
Questionnaire on ability to complete daily task. 10% increments with 100% meaning an individual is completely independent when it comes to completing daily activities |
Baseline |
|
Secondary |
Rapid Eye Movement Behavior Disorder Questionnaire |
Questionnaire measuring sleep behavior. Maximum points: 13 (a high score is indicative of RBD sleep disorder) |
Baseline |
|
Secondary |
Epworth Sleepiness Scale |
Questionnaire measuring sleepiness. Maximum points: 24 (high score indicates sleepiness) |
Baseline |
|
Secondary |
University of Pennsylvania Smell Identification Test |
Test measuring sense of smell. Maximum points: 40 (the higher the score, the more normal the smell) |
Baseline |
|